Detailed information of TA system TA113309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 5015035..5015600
• Replicon: chromosome
• Accession: NZ_CP033162
• Organism: Serratia sp. P2ACOL2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EBA31_RS24135
• Protein ID: WP_122080381.1
• Coordinates: 5015322..5015600 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A380ARC2
• Locus tag: EBA31_RS24130
• Protein ID: WP_020837302.1
• Coordinates: 5015035..5015304 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA31_RS24115	5011248..5012465	-	1218	WP_115060714.1	aspartate aminotransferase family protein	-
EBA31_RS24120	5012597..5013172	-	576	WP_122080380.1	aminodeoxychorismate synthase component II	-
EBA31_RS24125	5013283..5014809	-	1527	WP_115060716.1	DUF853 family protein	-
EBA31_RS24130	5015035..5015304	+	270	WP_020837302.1	hypothetical protein	Antitoxin
EBA31_RS24135	5015322..5015600	+	279	WP_122080381.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EBA31_RS24140	5015601..5016326	-	726	WP_020837306.1	two-component system response regulator BtsR	-
EBA31_RS24145	5016326..5018010	-	1685	Protein_4681	sensor histidine kinase	-
EBA31_RS24150	5018172..5018741	-	570	WP_020837308.1	peptidylprolyl isomerase A	-
EBA31_RS24155	5019099..5019437	+	339	WP_041415733.1	PTS lactose/cellobiose transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10331.92 Da
• Isoelectric Point: 9.8344

>T113309 WP_122080381.1 NZ_CP033162:5015322-5015600 [Serratia sp. P2ACOL2]
VKLKWTDPAIADRMAIYDYLASKNPIAAAEIDALISAAASQLSRNPSSGKVGRVSGTREWVIHHFYLLTYEVKNDLLIIL
AVVHSRRQWPKD

Nucleotide

• Length: 279 bp

>T113309 NZ_CP033162:5015322-5015600 [Serratia sp. P2ACOL2]
GTGAAGCTAAAGTGGACGGATCCCGCAATTGCTGACCGTATGGCAATTTATGACTATCTTGCGTCAAAGAACCCGATAGC
TGCCGCAGAGATTGATGCTTTGATTTCTGCGGCGGCAAGCCAACTATCCCGAAACCCATCAAGTGGCAAAGTGGGCCGGG
TTTCAGGTACACGTGAATGGGTCATTCATCATTTTTACCTACTGACTTATGAAGTAAAAAATGACCTTCTTATTATTTTG
GCAGTCGTACATTCCCGCCGGCAATGGCCAAAGGATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.64 Da
• Isoelectric Point: 5.2281

>AT113309 WP_020837302.1 NZ_CP033162:5015035-5015304 [Serratia sp. P2ACOL2]
MSESTVVIRVDDELKIAFASAAKAADRTASQLLRDFMRDFVSRQSQQKEYEQWLQEKVDLSRKALQEGRVVDNEDVEAYF
AERRAKSMR

Nucleotide

• Length: 270 bp

>AT113309 NZ_CP033162:5015035-5015304 [Serratia sp. P2ACOL2]
ATGTCTGAATCTACCGTGGTTATCCGCGTGGATGACGAGTTAAAAATAGCTTTTGCCAGCGCGGCCAAAGCAGCGGATCG
AACGGCATCTCAGCTTTTACGCGATTTCATGCGAGATTTTGTCAGTCGACAATCGCAGCAAAAAGAGTATGAACAGTGGT
TGCAGGAGAAGGTCGATTTAAGCCGAAAAGCGCTCCAGGAAGGAAGAGTGGTTGATAATGAGGACGTTGAGGCTTATTTC
GCCGAGCGCAGGGCAAAATCAATGCGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A380ARC2