Detailed information of TA system TA113307

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4565055..4565819
• Replicon: chromosome
• Accession: NZ_CP033162
• Organism: Serratia sp. P2ACOL2

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: EBA31_RS22055
• Protein ID: WP_122080220.1
• Coordinates: 4565451..4565819 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: EBA31_RS22050
• Protein ID: WP_122080219.1
• Coordinates: 4565055..4565396 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA31_RS22020	4561118..4562014	+	897	WP_122080215.1	50S ribosome-binding GTPase	-
EBA31_RS22025	4562263..4562817	+	555	WP_122080216.1	hypothetical protein	-
EBA31_RS22030	4563060..4563338	+	279	WP_202914232.1	hypothetical protein	-
EBA31_RS22035	4563500..4563856	+	357	WP_122080217.1	hypothetical protein	-
EBA31_RS22040	4564072..4564530	+	459	WP_122080218.1	antirestriction protein	-
EBA31_RS22045	4564567..4565043	+	477	WP_122080674.1	DNA repair protein RadC	-
EBA31_RS22050	4565055..4565396	+	342	WP_122080219.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EBA31_RS22055	4565451..4565819	+	369	WP_122080220.1	TA system toxin CbtA family protein	Toxin
EBA31_RS22060	4565816..4566145	+	330	WP_122080221.1	hypothetical protein	-
EBA31_RS22065	4566252..4567100	+	849	WP_122080222.1	DUF4942 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4528520..4574058	45538

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13620.56 Da
• Isoelectric Point: 7.7817

>T113307 WP_122080220.1 NZ_CP033162:4565451-4565819 [Serratia sp. P2ACOL2]
MQTVSASPKRETQPCPSPVAVWQSLLTHLLAQHYGLTLSDTAFSDDTVILEHIDAGISLADALNFIVEKFDLVRTDRTGF
SCREQSPFVTAIDILRARRACGLMTRRGYRTITQTLQGEKRP

Nucleotide

• Length: 369 bp

>T113307 NZ_CP033162:4565451-4565819 [Serratia sp. P2ACOL2]
ATGCAAACAGTATCAGCATCCCCAAAACGGGAGACTCAGCCCTGCCCGTCACCTGTTGCCGTCTGGCAATCCTTGCTCAC
ACACCTGCTGGCGCAGCATTACGGCCTGACGCTGAGCGATACCGCGTTCAGCGATGATACCGTCATCCTGGAACACATCG
ATGCCGGCATCTCGCTGGCCGATGCGTTGAATTTTATTGTGGAGAAGTTTGATCTGGTTCGCACCGATCGAACGGGGTTT
TCCTGCCGCGAACAATCCCCTTTCGTCACCGCCATCGATATTCTTCGCGCTCGACGGGCCTGTGGCCTGATGACCCGACG
TGGTTACCGCACCATTACGCAGACCCTCCAGGGGGAAAAGCGCCCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12600.31 Da
• Isoelectric Point: 7.3809

>AT113307 WP_122080219.1 NZ_CP033162:4565055-4565396 [Serratia sp. P2ACOL2]
MPSINVPAWGLKRSITPQLGARLVQQGNRLHYLTDRAGICGTFSEVQARSLDTAFPQFINHLELMLLSGELNPRYQHGVT
LYRDGLTCEADSLGSHGYIYISIYPTHEAPTKN

Nucleotide

• Length: 342 bp

>AT113307 NZ_CP033162:4565055-4565396 [Serratia sp. P2ACOL2]
ATGCCTTCAATCAATGTCCCCGCCTGGGGCCTGAAACGCAGCATCACTCCGCAGTTGGGTGCCCGCCTGGTACAGCAAGG
TAACCGACTCCATTATCTGACCGACCGTGCCGGCATCTGCGGTACCTTCAGTGAAGTGCAGGCCCGTTCACTGGATACTG
CCTTCCCGCAGTTTATCAACCATCTGGAACTGATGCTGTTGTCCGGGGAACTCAATCCCCGGTATCAGCACGGCGTCACG
CTGTACCGTGACGGATTGACGTGCGAGGCAGACAGCCTCGGATCGCACGGCTACATCTATATATCGATTTATCCGACACA
CGAAGCACCCACGAAAAACTGA