Detailed information of TA system TA113306

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4363256..4363925
• Replicon: chromosome
• Accession: NZ_CP033162
• Organism: Serratia sp. P2ACOL2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EBA31_RS21070
• Protein ID: WP_122080130.1
• Coordinates: 4363256..4363678 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7W4F6J9
• Locus tag: EBA31_RS21075
• Protein ID: WP_020828476.1
• Coordinates: 4363659..4363925 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA31_RS21050	4359142..4359660	+	519	WP_020828471.1	flavodoxin FldB	-
EBA31_RS21055	4359697..4361061	-	1365	WP_122080129.1	cell envelope integrity protein CreD	-
EBA31_RS21060	4361146..4362564	-	1419	WP_046372715.1	two-component system sensor histidine kinase CreC	-
EBA31_RS21065	4362561..4363256	-	696	WP_046372714.1	two-component system response regulator CreB	-
EBA31_RS21070	4363256..4363678	-	423	WP_122080130.1	protein YgfX	Toxin
EBA31_RS21075	4363659..4363925	-	267	WP_020828476.1	FAD assembly factor SdhE	Antitoxin
EBA31_RS21080	4364248..4365234	+	987	WP_122080131.1	tRNA-modifying protein YgfZ	-
EBA31_RS21085	4365292..4365789	-	498	WP_020828478.1	DUF2165 domain-containing protein	-
EBA31_RS21090	4365954..4366628	-	675	WP_020828479.1	hemolysin III family protein	-
EBA31_RS21095	4366812..4367420	+	609	WP_122080132.1	HD domain-containing protein	-
EBA31_RS21100	4367461..4368786	-	1326	WP_122080133.1	MHS family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16572.53 Da
• Isoelectric Point: 10.6958

>T113306 WP_122080130.1 NZ_CP033162:c4363678-4363256 [Serratia sp. P2ACOL2]
VAQWRCDVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLEHQRVGWQGQ
EWQLAKQPWMLRFGILLTLQPMQGKKRRRLWLASDSMAKAEWRHLRQQLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T113306 NZ_CP033162:c4363678-4363256 [Serratia sp. P2ACOL2]
GTGGCCCAGTGGCGATGTGATGTTCGTATTTCCTGGCGCACCCAGTTACTTTCGCTGTTGACGCATGGCGTTCTGATCCT
GCTGATCCTGATTTCACCCTGGCCGGAAGGCTACGGGCCAATCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTGAATGCA
TACGTAGCCAAAAACGCATTGCGTCGCGTCAGGGGGAGTTACGCCTGCTGGAGCACCAGCGTGTGGGCTGGCAAGGCCAG
GAATGGCAGTTGGCCAAGCAACCCTGGATGCTGCGCTTCGGTATTCTGCTGACGTTGCAACCGATGCAGGGGAAAAAGCG
TCGTCGCTTATGGTTGGCCTCCGACAGCATGGCCAAGGCCGAATGGCGACATTTGCGCCAACAGCTGTTGTATCCACCGG
CCAGTGATGATGAGGAACCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.99 Da
• Isoelectric Point: 5.0990

>AT113306 WP_020828476.1 NZ_CP033162:c4363925-4363659 [Serratia sp. P2ACOL2]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDRLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT113306 NZ_CP033162:c4363925-4363659 [Serratia sp. P2ACOL2]
ATGGATATTAATAACAAAGCACGTATTCACTGGGCTTGTCGCCGTGGCATGCGTGAGCTGGACATCTCGATCATGCCGTT
CTTCGAATATGAGTACGATCGGTTGAATGACACAGACAAAGCGCTGTTTATCCGCCTGCTTGAGAGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCTCCGCAGGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F6J9