Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3992440..3993092 Replicon chromosome
Accession NZ_CP033162
Organism Serratia sp. P2ACOL2

Toxin (Protein)


Gene name vapC Uniprot ID A0A379YFT9
Locus tag EBA31_RS19350 Protein ID WP_020828096.1
Coordinates 3992440..3992826 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A379YGI8
Locus tag EBA31_RS19355 Protein ID WP_020828097.1
Coordinates 3992829..3993092 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EBA31_RS19335 3988905..3990335 + 1431 WP_020828093.1 MFS transporter -
EBA31_RS19340 3990335..3991717 + 1383 WP_046372938.1 two-component system sensor histidine kinase BaeS -
EBA31_RS19345 3991717..3992433 + 717 WP_020828095.1 two-component system response regulator BaeR -
EBA31_RS19350 3992440..3992826 - 387 WP_020828096.1 type II toxin-antitoxin system VapC family toxin Toxin
EBA31_RS19355 3992829..3993092 - 264 WP_020828097.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EBA31_RS19360 3993444..3993782 + 339 WP_020828098.1 YegP family protein -
EBA31_RS19365 3994083..3995434 + 1352 Protein_3755 tRNA 5-hydroxyuridine modification protein YegQ -
EBA31_RS19370 3995908..3996825 + 918 WP_020828101.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14093.28 Da        Isoelectric Point: 7.8799

>T113304 WP_020828096.1 NZ_CP033162:c3992826-3992440 [Serratia sp. P2ACOL2]
MYMFDTNTVSQLFRRHPRLLSLMEKIPPSAVCISSITQAELLYGVAKRQNLALKATVAAFLDSVTVYAWDSEAAHCYGTL
RAEMTQKGRVMGALDQLIAAHAQSRGATIVTNDRAFAMVPGLTVEDWT

Download         Length: 387 bp

>T113304 NZ_CP033162:c3992826-3992440 [Serratia sp. P2ACOL2]
ATGTATATGTTTGACACCAATACGGTCAGCCAACTGTTCCGTCGGCATCCCCGCTTGCTGAGCCTAATGGAAAAAATCCC
GCCTTCTGCGGTATGCATTTCCAGCATTACGCAGGCGGAACTGCTTTATGGCGTAGCCAAGCGGCAGAACCTTGCGCTGA
AAGCGACGGTCGCGGCATTTCTTGATTCCGTGACGGTATATGCCTGGGACAGTGAAGCCGCGCATTGCTATGGCACGCTG
CGGGCGGAAATGACGCAAAAGGGGCGGGTGATGGGGGCCCTGGATCAGCTTATTGCCGCCCACGCGCAGAGCCGCGGAGC
GACAATAGTGACTAACGACCGGGCGTTTGCCATGGTGCCAGGCCTGACGGTAGAAGACTGGACCTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10091.38 Da        Isoelectric Point: 5.8701

>AT113304 WP_020828097.1 NZ_CP033162:c3993092-3992829 [Serratia sp. P2ACOL2]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIEKTQVPHDFLAADERQQGSATR
DPFAGEE

Download         Length: 264 bp

>AT113304 NZ_CP033162:c3993092-3992829 [Serratia sp. P2ACOL2]
ATGGAAAGGGTCGCGAAACTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTCGAATTTGATACAGA
TCGTGTGTATATCCGCCGCGATCGGGAGGGAAACGTGATTTTATCTAAATATCCGGCCAAACCTGACAGCTGGGCTCCGC
TGCTGCAAATGATCGAAAAAACGCAGGTACCGCATGACTTTCTGGCGGCTGATGAACGTCAGCAGGGCAGTGCCACCCGC
GATCCGTTCGCCGGGGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379YFT9

Antitoxin

Source ID Structure
AlphaFold DB A0A379YGI8

References