Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 3992440..3993092 | Replicon | chromosome |
Accession | NZ_CP033162 | ||
Organism | Serratia sp. P2ACOL2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A379YFT9 |
Locus tag | EBA31_RS19350 | Protein ID | WP_020828096.1 |
Coordinates | 3992440..3992826 (-) | Length | 129 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A379YGI8 |
Locus tag | EBA31_RS19355 | Protein ID | WP_020828097.1 |
Coordinates | 3992829..3993092 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EBA31_RS19335 | 3988905..3990335 | + | 1431 | WP_020828093.1 | MFS transporter | - |
EBA31_RS19340 | 3990335..3991717 | + | 1383 | WP_046372938.1 | two-component system sensor histidine kinase BaeS | - |
EBA31_RS19345 | 3991717..3992433 | + | 717 | WP_020828095.1 | two-component system response regulator BaeR | - |
EBA31_RS19350 | 3992440..3992826 | - | 387 | WP_020828096.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
EBA31_RS19355 | 3992829..3993092 | - | 264 | WP_020828097.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
EBA31_RS19360 | 3993444..3993782 | + | 339 | WP_020828098.1 | YegP family protein | - |
EBA31_RS19365 | 3994083..3995434 | + | 1352 | Protein_3755 | tRNA 5-hydroxyuridine modification protein YegQ | - |
EBA31_RS19370 | 3995908..3996825 | + | 918 | WP_020828101.1 | lipid kinase YegS | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14093.28 Da Isoelectric Point: 7.8799
>T113304 WP_020828096.1 NZ_CP033162:c3992826-3992440 [Serratia sp. P2ACOL2]
MYMFDTNTVSQLFRRHPRLLSLMEKIPPSAVCISSITQAELLYGVAKRQNLALKATVAAFLDSVTVYAWDSEAAHCYGTL
RAEMTQKGRVMGALDQLIAAHAQSRGATIVTNDRAFAMVPGLTVEDWT
MYMFDTNTVSQLFRRHPRLLSLMEKIPPSAVCISSITQAELLYGVAKRQNLALKATVAAFLDSVTVYAWDSEAAHCYGTL
RAEMTQKGRVMGALDQLIAAHAQSRGATIVTNDRAFAMVPGLTVEDWT
Download Length: 387 bp
>T113304 NZ_CP033162:c3992826-3992440 [Serratia sp. P2ACOL2]
ATGTATATGTTTGACACCAATACGGTCAGCCAACTGTTCCGTCGGCATCCCCGCTTGCTGAGCCTAATGGAAAAAATCCC
GCCTTCTGCGGTATGCATTTCCAGCATTACGCAGGCGGAACTGCTTTATGGCGTAGCCAAGCGGCAGAACCTTGCGCTGA
AAGCGACGGTCGCGGCATTTCTTGATTCCGTGACGGTATATGCCTGGGACAGTGAAGCCGCGCATTGCTATGGCACGCTG
CGGGCGGAAATGACGCAAAAGGGGCGGGTGATGGGGGCCCTGGATCAGCTTATTGCCGCCCACGCGCAGAGCCGCGGAGC
GACAATAGTGACTAACGACCGGGCGTTTGCCATGGTGCCAGGCCTGACGGTAGAAGACTGGACCTAG
ATGTATATGTTTGACACCAATACGGTCAGCCAACTGTTCCGTCGGCATCCCCGCTTGCTGAGCCTAATGGAAAAAATCCC
GCCTTCTGCGGTATGCATTTCCAGCATTACGCAGGCGGAACTGCTTTATGGCGTAGCCAAGCGGCAGAACCTTGCGCTGA
AAGCGACGGTCGCGGCATTTCTTGATTCCGTGACGGTATATGCCTGGGACAGTGAAGCCGCGCATTGCTATGGCACGCTG
CGGGCGGAAATGACGCAAAAGGGGCGGGTGATGGGGGCCCTGGATCAGCTTATTGCCGCCCACGCGCAGAGCCGCGGAGC
GACAATAGTGACTAACGACCGGGCGTTTGCCATGGTGCCAGGCCTGACGGTAGAAGACTGGACCTAG
Antitoxin
Download Length: 88 a.a. Molecular weight: 10091.38 Da Isoelectric Point: 5.8701
>AT113304 WP_020828097.1 NZ_CP033162:c3993092-3992829 [Serratia sp. P2ACOL2]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIEKTQVPHDFLAADERQQGSATR
DPFAGEE
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIEKTQVPHDFLAADERQQGSATR
DPFAGEE
Download Length: 264 bp
>AT113304 NZ_CP033162:c3993092-3992829 [Serratia sp. P2ACOL2]
ATGGAAAGGGTCGCGAAACTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTCGAATTTGATACAGA
TCGTGTGTATATCCGCCGCGATCGGGAGGGAAACGTGATTTTATCTAAATATCCGGCCAAACCTGACAGCTGGGCTCCGC
TGCTGCAAATGATCGAAAAAACGCAGGTACCGCATGACTTTCTGGCGGCTGATGAACGTCAGCAGGGCAGTGCCACCCGC
GATCCGTTCGCCGGGGAAGAGTAA
ATGGAAAGGGTCGCGAAACTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTCGAATTTGATACAGA
TCGTGTGTATATCCGCCGCGATCGGGAGGGAAACGTGATTTTATCTAAATATCCGGCCAAACCTGACAGCTGGGCTCCGC
TGCTGCAAATGATCGAAAAAACGCAGGTACCGCATGACTTTCTGGCGGCTGATGAACGTCAGCAGGGCAGTGCCACCCGC
GATCCGTTCGCCGGGGAAGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A379YFT9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A379YGI8 |