Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3499291..3499881 Replicon chromosome
Accession NZ_CP033162
Organism Serratia sp. P2ACOL2

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag EBA31_RS17100 Protein ID WP_122079816.1
Coordinates 3499291..3499623 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag EBA31_RS17105 Protein ID WP_122079817.1
Coordinates 3499624..3499881 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EBA31_RS17080 3495712..3496419 + 708 WP_020827675.1 heavy metal response regulator transcription factor -
EBA31_RS17085 3496416..3497873 + 1458 WP_122079814.1 heavy metal sensor histidine kinase -
EBA31_RS17090 3497875..3498798 - 924 WP_122079815.1 nitrogen assimilation transcriptional regulator NAC -
EBA31_RS17100 3499291..3499623 - 333 WP_122079816.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EBA31_RS17105 3499624..3499881 - 258 WP_122079817.1 antitoxin Antitoxin
EBA31_RS17115 3500078..3500281 - 204 WP_122079818.1 hypothetical protein -
EBA31_RS17120 3500449..3501426 + 978 WP_122080650.1 DUF1852 domain-containing protein -
EBA31_RS17125 3501454..3502485 + 1032 WP_122079819.1 methionine synthase -
EBA31_RS17135 3503078..3503677 + 600 WP_046373148.1 hypothetical protein -
EBA31_RS17140 3503711..3504643 - 933 WP_122079821.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11841.67 Da        Isoelectric Point: 10.2965

>T113303 WP_122079816.1 NZ_CP033162:c3499623-3499291 [Serratia sp. P2ACOL2]
MDRGEIWLVSLDPTAGHEQSGSRPVLIVSKASFNKFTRLPVIVPVTSGGNFARMAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARSGKRLERLPDSIMNEVLGRLEAILT

Download         Length: 333 bp

>T113303 NZ_CP033162:c3499623-3499291 [Serratia sp. P2ACOL2]
ATGGACAGAGGCGAAATCTGGCTCGTTTCACTTGATCCGACTGCCGGGCATGAGCAAAGCGGAAGCCGACCGGTCCTCAT
CGTATCGAAGGCATCGTTTAACAAGTTCACCCGGTTACCCGTTATTGTTCCTGTGACCAGCGGCGGAAACTTTGCCCGCA
TGGCGGGGTTTACCGTATCACTGGATGGCGCAGGGACGAAAACAACGGGTGTTATTCGTTGCGACCAGCCCAGAACCATT
GATATGGGGGCTCGTAGCGGCAAACGACTGGAACGTCTACCTGACAGTATCATGAACGAGGTGCTGGGCAGGCTGGAAGC
TATTCTGACCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9350.85 Da        Isoelectric Point: 4.4488

>AT113303 WP_122079817.1 NZ_CP033162:c3499881-3499624 [Serratia sp. P2ACOL2]
MYTTRLKKVGGSVMLAVPPAVLKTLALSADSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHVEISEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT113303 NZ_CP033162:c3499881-3499624 [Serratia sp. P2ACOL2]
ATGTATACAACTCGCCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCTGCGGTGCTGAAAACGCTGGCGCT
GTCGGCGGACAGTGAGGTTGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGCTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGACCCGCATGTTGAAATAAGCGAGGAAGATCGGGAATGGATTGATGCGCCGGCTGTG
GGTAAGGAGATCTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References