Detailed information of TA system TA113302

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3252570..3253195
• Replicon: chromosome
• Accession: NZ_CP033162
• Organism: Serratia sp. P2ACOL2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A515CU05
• Locus tag: EBA31_RS15855
• Protein ID: WP_048760244.1
• Coordinates: 3252570..3252752 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EBA31_RS15860
• Protein ID: WP_048760245.1
• Coordinates: 3252782..3253195 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA31_RS15850	3248432..3252403	+	3972	WP_122079692.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
EBA31_RS15855	3252570..3252752	+	183	WP_048760244.1	type II toxin-antitoxin system HicA family toxin	Toxin
EBA31_RS15860	3252782..3253195	+	414	WP_048760245.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EBA31_RS15865	3253227..3253979	-	753	WP_046373263.1	L-cystine ABC transporter ATP-binding protein YecC	-
EBA31_RS15870	3253983..3254645	-	663	WP_020827487.1	cystine ABC transporter permease	-
EBA31_RS15875	3254645..3255445	-	801	WP_046373262.1	cystine ABC transporter substrate-binding protein	-
EBA31_RS15880	3255560..3256552	-	993	WP_122079693.1	D-cysteine desulfhydrase	-
EBA31_RS15885	3256680..3257189	-	510	WP_041414695.1	flagella biosynthesis regulatory protein FliZ	-
EBA31_RS15890	3257248..3257970	-	723	WP_020827491.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliZ / fliA	3246391..3257970	11579

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6768.95 Da
• Isoelectric Point: 10.7801

>T113302 WP_048760244.1 NZ_CP033162:3252570-3252752 [Serratia sp. P2ACOL2]
VKSSELIGLLEQEGWVLTRIKGSHHQFKHPNSRLVITVPHPRKDLKAGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T113302 NZ_CP033162:3252570-3252752 [Serratia sp. P2ACOL2]
GTGAAAAGTTCAGAACTGATCGGGCTATTAGAACAGGAAGGTTGGGTTTTAACGCGGATCAAGGGAAGCCACCATCAGTT
TAAGCACCCGAACTCCCGTCTGGTGATCACCGTCCCACACCCGCGAAAGGATCTGAAAGCGGGGACGCTGCGCCAAATCA
TGAAAGATGCCGGATTGTGCTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15093.75 Da
• Isoelectric Point: 4.8403

>AT113302 WP_048760245.1 NZ_CP033162:3252782-3253195 [Serratia sp. P2ACOL2]
MFYPAYVHSEPDGSASGFFPDVPGCYFAGDTLDRAFEDARSALDAHFEFLSEDNQPIPGPQAVTFHLAQNNDSLNGGQWL
LVNINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Nucleotide

• Length: 414 bp

>AT113302 NZ_CP033162:3252782-3253195 [Serratia sp. P2ACOL2]
ATGTTCTACCCTGCTTATGTACATTCTGAACCGGACGGCAGTGCCAGCGGCTTCTTTCCCGATGTGCCAGGCTGCTATTT
TGCCGGAGATACCCTGGACAGAGCCTTTGAAGACGCCAGAAGTGCGCTGGATGCCCATTTCGAATTCTTGAGCGAAGACA
ATCAGCCCATTCCCGGCCCACAGGCCGTGACCTTTCATCTGGCACAGAATAACGACAGTCTGAATGGCGGGCAGTGGTTG
TTGGTCAATATTAATATGGATAAGTTTGATGGTCGGGCGGAGCGTATCAATATTACCTTGCCGCACCGGCTGCTGAACCG
CATAGATTCTCTGGTGCAGCAGCATCCCGGTTACGGTAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGCAATGAATTAT
TGAAAGCCGGGTAG

Structures

Toxin

• AlphaFold DB: A0A515CU05