Detailed information of TA system TA113293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1520397..1520992
• Replicon: chromosome
• Accession: NZ_CP033162
• Organism: Serratia sp. P2ACOL2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: EBA31_RS07265
• Protein ID: WP_071605322.1
• Coordinates: 1520397..1520651 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EBA31_RS07270
• Protein ID: WP_063988754.1
• Coordinates: 1520651..1520992 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA31_RS07225	1515621..1515863	+	243	WP_122078013.1	DUF2732 family protein	-
EBA31_RS07230	1515863..1516174	+	312	WP_122078016.1	DUF5405 family protein	-
EBA31_RS07235	1516174..1516398	+	225	WP_122078018.1	TraR/DksA C4-type zinc finger protein	-
EBA31_RS07240	1516521..1516802	+	282	WP_122078021.1	DUF5405 family protein	-
EBA31_RS07245	1516792..1517307	+	516	WP_122078023.1	hypothetical protein	-
EBA31_RS07250	1517304..1519520	+	2217	WP_122078026.1	replication endonuclease	-
EBA31_RS07255	1519559..1519783	+	225	WP_060445968.1	hypothetical protein	-
EBA31_RS07260	1519831..1520028	+	198	WP_162302870.1	hypothetical protein	-
EBA31_RS07265	1520397..1520651	+	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
EBA31_RS07270	1520651..1520992	+	342	WP_063988754.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EBA31_RS07275	1521158..1522468	+	1311	WP_122078031.1	DUF3644 domain-containing protein	-
EBA31_RS07280	1522499..1523533	-	1035	WP_122078033.1	phage portal protein	-
EBA31_RS07285	1523533..1525305	-	1773	WP_122078036.1	terminase ATPase subunit family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1511443..1545214	33771

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T113293 WP_071605322.1 NZ_CP033162:1520397-1520651 [Serratia sp. P2ACOL2]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T113293 NZ_CP033162:1520397-1520651 [Serratia sp. P2ACOL2]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCCAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12390.89 Da
• Isoelectric Point: 4.4537

>AT113293 WP_063988754.1 NZ_CP033162:1520651-1520992 [Serratia sp. P2ACOL2]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECQKDGIEPYKSYSGKVTTRLSP
ERHQALALAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT113293 NZ_CP033162:1520651-1520992 [Serratia sp. P2ACOL2]
ATGAACAATACACTGAAAATTGACGGTCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCAGAGGCGAGTT
TGTCGGGCTGAACGGTGGTGCTGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCAAAAAGACGGCATCGAGCCCTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGCTAGCCCTTGCCGCACAGGCCACCGGGCAGTCGATTAACGAGCTGCTGAATGAAGGCGTTGATTT
AGTTATCGAAAAACACTCATGA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1