Detailed information of TA system TA113291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipB(antitoxin)
• Location: 322953..323407
• Replicon: chromosome
• Accession: NZ_CP033162
• Organism: Serratia sp. P2ACOL2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: EBA31_RS01615
• Protein ID: WP_122076868.1
• Coordinates: 323204..323407 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: EBA31_RS01610
• Protein ID: WP_012005023.1
• Coordinates: 322953..323201 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA31_RS01585	318642..319712	+	1071	WP_020825022.1	LPS export ABC transporter permease LptG	-
EBA31_RS01595	320337..320456	-	120	Protein_292	IS3 family transposase	-
EBA31_RS01600	320774..321850	+	1077	WP_122076864.1	Fic family protein	-
EBA31_RS01605	322105..322740	+	636	WP_012005022.1	carbonic anhydrase	-
EBA31_RS01610	322953..323201	+	249	WP_012005023.1	helix-turn-helix domain-containing protein	Antitoxin
EBA31_RS01615	323204..323407	+	204	WP_122076868.1	HipA N-terminal domain-containing protein	Toxin
EBA31_RS01620	324011..325018	-	1008	WP_122080572.1	DUF4917 family protein	-
EBA31_RS01625	325295..326530	+	1236	WP_122076872.1	DNA cytosine methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	320774..340441	19667

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-63)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7564.76 Da
• Isoelectric Point: 8.6418

>T113291 WP_122076868.1 NZ_CP033162:323204-323407 [Serratia sp. P2ACOL2]
MEKLRVALNGTVVGTLEKHAGGAMSFVYHEEWLTQAGARAISLSLPLQPEPFRGDVVYNFFRQFIIR

Nucleotide

• Length: 204 bp

>T113291 NZ_CP033162:323204-323407 [Serratia sp. P2ACOL2]
ATGGAAAAGCTACGCGTGGCGCTGAATGGTACTGTTGTAGGGACGCTGGAAAAGCATGCAGGCGGCGCGATGTCGTTTGT
TTACCACGAGGAGTGGCTGACACAAGCCGGTGCGCGCGCCATATCGTTATCCCTGCCGCTACAACCAGAACCATTCCGCG
GTGATGTGGTGTATAACTTTTTTCGACAATTCATTATTCGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9279.56 Da
• Isoelectric Point: 10.3139

>AT113291 WP_012005023.1 NZ_CP033162:322953-323201 [Serratia sp. P2ACOL2]
MKITSAQMLAHTLRNERKKRNQSQSKTADSVGLKQATVSAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Nucleotide

• Length: 249 bp

>AT113291 NZ_CP033162:322953-323201 [Serratia sp. P2ACOL2]
ATGAAAATCACCTCGGCACAGATGCTGGCGCATACATTACGCAACGAGCGTAAAAAGCGTAACCAAAGCCAAAGCAAAAC
CGCTGACAGTGTTGGGTTAAAACAGGCGACGGTTTCCGCGTTTGAAAACAACCCGGACGGTACCCGGCTGGAGACGTTGT
TCAAACTGCTTGCTGCGCTGGACTTGGAACTGCAGGTCACCCCGCGTGGCAAGCCGGTCGATCCCAAGACCTGGGATCAG
GAGTGGTGA