Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1049239..1049798 Replicon chromosome
Accession NZ_CP033144
Organism Vibrio owensii strain V180403

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag D0856_RS05265 Protein ID WP_005398411.1
Coordinates 1049239..1049517 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag D0856_RS05270 Protein ID WP_005398409.1
Coordinates 1049514..1049798 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0856_RS05200 1044311..1045144 + 834 WP_122067396.1 EcsC family protein -
D0856_RS05210 1045276..1045971 + 696 WP_122067397.1 FRG domain-containing protein -
D0856_RS30530 1046310..1046459 + 150 WP_163000571.1 hypothetical protein -
D0856_RS05220 1046628..1047188 + 561 WP_049877106.1 YdcF family protein -
D0856_RS05225 1047203..1047295 + 93 WP_198039109.1 DUF3265 domain-containing protein -
D0856_RS05230 1047331..1047708 + 378 WP_122067398.1 hypothetical protein -
D0856_RS05235 1047693..1047815 + 123 WP_082314566.1 DUF3265 domain-containing protein -
D0856_RS05240 1047909..1048265 + 357 WP_122067399.1 hypothetical protein -
D0856_RS05245 1048366..1048455 + 90 WP_071881309.1 DUF3265 domain-containing protein -
D0856_RS05250 1048484..1048753 - 270 WP_122067401.1 type II toxin-antitoxin system RelE/ParE family toxin -
D0856_RS05255 1048758..1049042 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
D0856_RS05260 1049119..1049210 + 92 Protein_999 DUF3265 domain-containing protein -
D0856_RS05265 1049239..1049517 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
D0856_RS05270 1049514..1049798 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D0856_RS05275 1049875..1049988 + 114 WP_122067402.1 DUF3265 domain-containing protein -
D0856_RS05280 1050032..1050526 - 495 WP_023623381.1 hypothetical protein -
D0856_RS05285 1050649..1050741 + 93 WP_122067403.1 DUF3265 domain-containing protein -
D0856_RS05290 1050769..1051068 + 300 WP_122067404.1 hypothetical protein -
D0856_RS05295 1051065..1051187 + 123 WP_122067405.1 DUF3265 domain-containing protein -
D0856_RS05300 1051250..1051762 + 513 WP_122067406.1 hypothetical protein -
D0856_RS05305 1051781..1051873 + 93 WP_122067407.1 DUF3265 domain-containing protein -
D0856_RS05310 1051924..1053372 + 1449 WP_206387563.1 caspase family protein -
D0856_RS05320 1053928..1054017 + 90 WP_123768104.1 DUF3265 domain-containing protein -
D0856_RS05325 1054050..1054445 + 396 WP_122067411.1 hypothetical protein -
D0856_RS05330 1054468..1054557 + 90 WP_072039143.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1003789..1099087 95298
- inside Integron - - 1002589..1090257 87668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T113250 WP_005398411.1 NZ_CP033144:c1049517-1049239 [Vibrio owensii]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T113250 NZ_CP033144:c1049517-1049239 [Vibrio owensii]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTGATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT113250 WP_005398409.1 NZ_CP033144:c1049798-1049514 [Vibrio owensii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT113250 NZ_CP033144:c1049798-1049514 [Vibrio owensii]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References