Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1015999..1016558 Replicon chromosome
Accession NZ_CP033144
Organism Vibrio owensii strain V180403

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag D0856_RS04825 Protein ID WP_005398411.1
Coordinates 1015999..1016277 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag D0856_RS04830 Protein ID WP_005398409.1
Coordinates 1016274..1016558 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0856_RS04750 1011238..1011627 + 390 WP_122067354.1 DUF4345 domain-containing protein -
D0856_RS30730 1011645..1011734 + 90 WP_071881309.1 DUF3265 domain-containing protein -
D0856_RS04760 1011760..1012317 + 558 WP_122067355.1 nucleotidyltransferase family protein -
D0856_RS30735 1012340..1012432 + 93 WP_005536857.1 DUF3265 domain-containing protein -
D0856_RS04775 1012959..1013050 + 92 Protein_911 DUF3265 domain-containing protein -
D0856_RS04790 1013538..1013669 + 132 WP_122067358.1 DUF3265 domain-containing protein -
D0856_RS04795 1013703..1014422 + 720 WP_122067359.1 hypothetical protein -
D0856_RS04800 1014437..1014529 + 93 WP_072884142.1 DUF3265 domain-containing protein -
D0856_RS04805 1014562..1015011 + 450 WP_122067360.1 metal ABC transporter ATPase -
D0856_RS04810 1015053..1015142 + 90 WP_206387583.1 DUF3265 domain-containing protein -
D0856_RS04815 1015185..1015853 + 669 WP_122067362.1 hypothetical protein -
D0856_RS04820 1015881..1015970 + 90 WP_122068866.1 DUF3265 domain-containing protein -
D0856_RS04825 1015999..1016277 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
D0856_RS04830 1016274..1016558 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D0856_RS04835 1016635..1016736 + 102 Protein_921 DUF3265 domain-containing protein -
D0856_RS04840 1016773..1017591 + 819 WP_122068868.1 DUF2971 domain-containing protein -
D0856_RS04845 1017611..1017703 + 93 WP_122067363.1 DUF3265 domain-containing protein -
D0856_RS04850 1018158..1018250 + 93 WP_017821981.1 DUF3265 domain-containing protein -
D0856_RS04855 1018298..1018885 + 588 WP_038880370.1 sugar O-acetyltransferase -
D0856_RS04860 1018900..1018992 + 93 WP_079855765.1 DUF3265 domain-containing protein -
D0856_RS04865 1019037..1019453 + 417 WP_163000628.1 GNAT family N-acetyltransferase -
D0856_RS04870 1019479..1019571 + 93 WP_206169873.1 DUF3265 domain-containing protein -
D0856_RS04875 1019598..1020008 + 411 WP_031847708.1 hydrolase -
D0856_RS04880 1019998..1020132 + 135 WP_122067366.1 DUF3265 domain-containing protein -
D0856_RS04885 1020219..1020779 + 561 WP_058666954.1 hypothetical protein -
D0856_RS04890 1020795..1020926 + 132 WP_206387584.1 DUF3265 domain-containing protein -
D0856_RS04895 1020923..1021432 + 510 WP_122067368.1 DUF4303 domain-containing protein -
D0856_RS30740 1021455..1021547 + 93 WP_086375043.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1003789..1099087 95298
- inside Integron - - 1002589..1090257 87668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T113248 WP_005398411.1 NZ_CP033144:c1016277-1015999 [Vibrio owensii]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T113248 NZ_CP033144:c1016277-1015999 [Vibrio owensii]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAATCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTATTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT113248 WP_005398409.1 NZ_CP033144:c1016558-1016274 [Vibrio owensii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT113248 NZ_CP033144:c1016558-1016274 [Vibrio owensii]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACAGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References