Detailed information of TA system TA113243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1483635..1484163
• Replicon: chromosome
• Accession: NZ_CP033141
• Organism: Vibrio parahaemolyticus strain 160807

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D0871_RS07950
• Protein ID: WP_069514421.1
• Coordinates: 1483635..1483925 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR02
• Locus tag: D0871_RS07955
• Protein ID: WP_005377003.1
• Coordinates: 1483915..1484163 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0871_RS07895	1478991..1479614	+	624	WP_015296930.1	hypothetical protein	-
D0871_RS07900	1479903..1480169	+	267	WP_023623448.1	hypothetical protein	-
D0871_RS07910	1480467..1480901	+	435	WP_023623449.1	hypothetical protein	-
D0871_RS07915	1480880..1481314	+	435	WP_029559564.1	hypothetical protein	-
D0871_RS07925	1481457..1481903	+	447	WP_023623451.1	hypothetical protein	-
D0871_RS07930	1481927..1482016	+	90	Protein_1360	DUF3265 domain-containing protein	-
D0871_RS07940	1482507..1482626	+	120	WP_164842025.1	DUF3265 domain-containing protein	-
D0871_RS07945	1482655..1483499	+	845	Protein_1362	HNH endonuclease	-
D0871_RS07950	1483635..1483925	-	291	WP_069514421.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0871_RS07955	1483915..1484163	-	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D0871_RS07960	1484431..1485354	+	924	WP_020838889.1	zinc dependent phospholipase C family protein	-
D0871_RS07965	1485351..1485749	+	399	WP_023623455.1	hypothetical protein	-
D0871_RS07970	1485902..1486474	+	573	WP_069514418.1	hypothetical protein	-
D0871_RS07975	1486687..1487037	+	351	WP_005500262.1	hypothetical protein	-
D0871_RS07980	1487164..1487542	-	379	Protein_1369	GNAT family N-acetyltransferase	-
D0871_RS07985	1487705..1488067	-	363	WP_023623457.1	VOC family protein	-
D0871_RS07990	1488182..1488628	-	447	WP_023623458.1	DUF3291 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1378306..1488628	110322
	-	inside	Integron	-	-	1378830..1487037	108207

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11276.27 Da
• Isoelectric Point: 10.6832

>T113243 WP_069514421.1 NZ_CP033141:c1483925-1483635 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKSMKRLDN

Nucleotide

• Length: 291 bp

>T113243 NZ_CP033141:c1483925-1483635 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGCCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAATCCATGAAAAGGTTAGATAATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT113243 WP_005377003.1 NZ_CP033141:c1484163-1483915 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT113243 NZ_CP033141:c1484163-1483915 [Vibrio parahaemolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCAGCATTCTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAACGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A347UR02