Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1437231..1437759 Replicon chromosome
Accession NZ_CP033141
Organism Vibrio parahaemolyticus strain 160807

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag D0871_RS07475 Protein ID WP_005377002.1
Coordinates 1437231..1437521 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag D0871_RS07480 Protein ID WP_005377003.1
Coordinates 1437511..1437759 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0871_RS07415 1432523..1432705 - 183 WP_023623386.1 hypothetical protein -
D0871_RS07420 1432788..1432928 + 141 WP_164842004.1 DUF3265 domain-containing protein -
D0871_RS07425 1433383..1433475 + 93 WP_075111389.1 DUF3265 domain-containing protein -
D0871_RS07430 1433496..1433945 + 450 WP_023623387.1 GNAT family N-acetyltransferase -
D0871_RS07435 1434081..1434779 + 699 WP_023623388.1 hypothetical protein -
D0871_RS07440 1434794..1434886 + 93 WP_005445235.1 DUF3265 domain-containing protein -
D0871_RS07445 1434914..1435330 - 417 WP_021486586.1 hypothetical protein -
D0871_RS07450 1435433..1435525 + 93 WP_079751125.1 DUF3265 domain-containing protein -
D0871_RS07455 1435567..1436001 + 435 WP_029853527.1 hypothetical protein -
D0871_RS27050 1436016..1436107 + 92 Protein_1276 DUF3265 domain-containing protein -
D0871_RS07465 1436629..1437105 + 477 WP_089183462.1 GNAT family N-acetyltransferase -
D0871_RS07470 1437090..1437212 + 123 WP_164842006.1 DUF3265 domain-containing protein -
D0871_RS07475 1437231..1437521 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0871_RS07480 1437511..1437759 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0871_RS27055 1437834..1437902 + 69 WP_074531725.1 DUF3265 domain-containing protein -
D0871_RS07490 1437952..1438200 + 249 WP_023622767.1 hypothetical protein -
D0871_RS07495 1438197..1438319 + 123 WP_079379530.1 DUF3265 domain-containing protein -
D0871_RS07500 1438341..1438808 + 468 WP_023623393.1 ASCH domain-containing protein -
D0871_RS07505 1438955..1439581 + 627 WP_042760754.1 hypothetical protein -
D0871_RS07510 1439687..1440040 + 354 WP_023623395.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
D0871_RS07515 1440204..1440614 + 411 WP_089183471.1 GFA family protein -
D0871_RS07520 1440654..1440731 + 78 WP_080257040.1 DUF3265 domain-containing protein -
D0871_RS07525 1441243..1441518 + 276 WP_023623398.1 hypothetical protein -
D0871_RS07530 1441532..1441993 + 462 WP_023623399.1 hypothetical protein -
D0871_RS07535 1442019..1442111 + 93 WP_005445734.1 DUF3265 domain-containing protein -
D0871_RS07540 1442139..1442618 + 480 WP_023623400.1 hypothetical protein -
D0871_RS07545 1442611..1442725 + 115 Protein_1293 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1378306..1488628 110322
- inside Integron - - 1378830..1487037 108207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T113242 WP_005377002.1 NZ_CP033141:c1437521-1437231 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T113242 NZ_CP033141:c1437521-1437231 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTACGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT113242 WP_005377003.1 NZ_CP033141:c1437759-1437511 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT113242 NZ_CP033141:c1437759-1437511 [Vibrio parahaemolyticus]
ATGACCACCAGAATCCTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAAAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References