Detailed information of TA system TA113241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1404478..1405025
• Replicon: chromosome
• Accession: NZ_CP033141
• Organism: Vibrio parahaemolyticus strain 160807

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D0871_RS07130
• Protein ID: WP_023623901.1
• Coordinates: 1404723..1405025 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Y3ZEQ4
• Locus tag: D0871_RS07125
• Protein ID: WP_015296907.1
• Coordinates: 1404478..1404735 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0871_RS07075	1399829..1399921	+	93	WP_005494807.1	DUF3265 domain-containing protein	-
D0871_RS07080	1400533..1400973	+	441	WP_021448683.1	hypothetical protein	-
D0871_RS07085	1401110..1401406	+	297	WP_023623898.1	hypothetical protein	-
D0871_RS07090	1401427..1401519	+	93	WP_079882431.1	DUF3265 domain-containing protein	-
D0871_RS07095	1401545..1401793	+	249	WP_023622767.1	hypothetical protein	-
D0871_RS07100	1401790..1401912	+	123	WP_079379530.1	DUF3265 domain-containing protein	-
D0871_RS07105	1401934..1402716	+	783	WP_023623899.1	hypothetical protein	-
D0871_RS07110	1402937..1403719	+	783	WP_023623900.1	hypothetical protein	-
D0871_RS07120	1403873..1404286	+	414	WP_069514106.1	hypothetical protein	-
D0871_RS07125	1404478..1404735	+	258	WP_015296907.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D0871_RS07130	1404723..1405025	+	303	WP_023623901.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0871_RS07140	1405497..1405622	+	126	WP_079882382.1	DUF3265 domain-containing protein	-
D0871_RS07145	1405759..1405962	+	204	WP_023623902.1	hypothetical protein	-
D0871_RS07150	1406565..1406657	+	93	WP_071652176.1	DUF3265 domain-containing protein	-
D0871_RS07155	1406677..1407036	+	360	WP_025523617.1	hypothetical protein	-
D0871_RS07160	1407245..1407835	+	591	WP_023623903.1	hypothetical protein	-
D0871_RS07165	1408536..1409468	+	933	WP_023623904.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1378306..1488628	110322
	-	inside	Integron	-	-	1378830..1487037	108207

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11793.73 Da
• Isoelectric Point: 5.1765

>T113241 WP_023623901.1 NZ_CP033141:1404723-1405025 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYMALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQYDDKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T113241 NZ_CP033141:1404723-1405025 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATGGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAATACGATGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAACAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9638.16 Da
• Isoelectric Point: 6.7269

>AT113241 WP_015296907.1 NZ_CP033141:1404478-1404735 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKMVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT113241 NZ_CP033141:1404478-1404735 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGATACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAATGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A7Y3ZEQ4