Detailed information of TA system TA113240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1382202..1382747
• Replicon: chromosome
• Accession: NZ_CP033141
• Organism: Vibrio parahaemolyticus strain 160807

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D0871_RS06885
• Protein ID: WP_017420806.1
• Coordinates: 1382202..1382498 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: D0871_RS06890
• Protein ID: WP_122015974.1
• Coordinates: 1382505..1382747 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0871_RS06855	1377705..1378292	+	588	WP_069513818.1	HD domain-containing protein	-
D0871_RS06860	1378306..1378779	+	474	WP_005458833.1	DUF2947 domain-containing protein	-
D0871_RS06865	1378830..1379792	-	963	WP_023623891.1	integron integrase	-
D0871_RS06875	1380592..1381506	+	915	WP_054730804.1	hypothetical protein	-
D0871_RS06880	1381613..1382017	+	405	WP_038969946.1	DUF2007 domain-containing protein	-
D0871_RS06885	1382202..1382498	-	297	WP_017420806.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0871_RS06890	1382505..1382747	-	243	WP_122015974.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D0871_RS06895	1382964..1383419	+	456	WP_038964950.1	GNAT family N-acetyltransferase	-
D0871_RS06900	1383416..1383538	+	123	WP_072601187.1	DUF3265 domain-containing protein	-
D0871_RS06910	1383998..1384075	+	78	WP_078231625.1	DUF3265 domain-containing protein	-
D0871_RS06915	1384121..1384978	+	858	WP_122015975.1	RNA helicase	-
D0871_RS06920	1385560..1386186	+	627	WP_122015976.1	hypothetical protein	-
D0871_RS06925	1386201..1386293	+	93	WP_080100239.1	DUF3265 domain-containing protein	-
D0871_RS06930	1386635..1386760	+	126	WP_122016080.1	DUF3265 domain-containing protein	-
D0871_RS06940	1387194..1387583	+	390	WP_061896955.1	DUF4144 domain-containing protein	-
D0871_RS06945	1387618..1387731	+	114	WP_122015977.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1378306..1488628	110322
	-	inside	Integron	-	-	1378830..1487037	108207

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11306.95 Da
• Isoelectric Point: 9.6425

>T113240 WP_017420806.1 NZ_CP033141:c1382498-1382202 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQTHLQKIRNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T113240 NZ_CP033141:c1382498-1382202 [Vibrio parahaemolyticus]
ATGCAAAAGAATAAATATAAGCTAAGTAAATTAGCACAGACTCATTTACAAAAAATCAGAAACTATACCGTCAACAATTT
CTCTGAGATGCAATGGCGAAGCTACAAAGATACCTTACTAACAGGGTTTCAAATGCTTGCTGACAACCCGGCTGTTGGTC
GCAGTTGCGATGAGATATACCCAAGTGGTTTTTATTTCCCTGTAGGCAAGCACACCGCTTACTTTACAAAAGAAGATGGC
TTCATTTTAGTTGTTGCTGTACTCGGTCAATCACAACTTCCGCAGAACCACCTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9001.19 Da
• Isoelectric Point: 5.0758

>AT113240 WP_122015974.1 NZ_CP033141:c1382747-1382505 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVNGEDFLNAL

Nucleotide

• Length: 243 bp

>AT113240 NZ_CP033141:c1382747-1382505 [Vibrio parahaemolyticus]
ATGCACACATTAACAGCAAATGATGCCAAACGTAATTTTGGTGAGTTACTTCTGAGCGCTCAACGTGAGCCAGTGAAAAT
TAGCAAAAATAGCAAAGATGCCGTAGTTGTTATGTCGATTAAAGACTATGAAGAGCTGGAGGCAATGAAAACTGATTACC
TGAGACATTGTTTCGAGTCAGCGAAGCAAGACTTGGCACAAGGCAATGTAGTTAATGGTGAAGACTTTTTAAACGCCTTA
TAA