Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 89313..89881 Replicon plasmid pVOWZ1
Accession NZ_CP033139
Organism Vibrio owensii strain 1700302

Toxin (Protein)


Gene name mazF Uniprot ID A0A1Y1BA95
Locus tag D0812_RS29555 Protein ID WP_023624650.1
Coordinates 89540..89881 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag D0812_RS29550 Protein ID WP_122016154.1
Coordinates 89313..89543 (+) Length 77 a.a.

Genomic Context

D0812_RS29530D0812_RS29540D0812_RS29550D0812_RS29555D0812_RS29520D0812_RS29525D0812_RS29545D0812_RS29560D0812_RS29565D0812_RS29575D0812_RS29580
Location: 86935..87156 (222 bp)
Type: Others
Protein ID: WP_023624649.1
Location: 87759..88142 (384 bp)
Type: Others
Protein ID: Protein_101
Location: 89313..89543 (231 bp)
Type: Antitoxin
Protein ID: WP_122016154.1
Location: 89540..89881 (342 bp)
Type: Toxin
Protein ID: WP_023624650.1
Location: 84686..85690 (1005 bp)
Type: Others
Protein ID: WP_159408506.1
Location: 86251..86625 (375 bp)
Type: Others
Protein ID: WP_127914005.1
Location: 88137..88862 (726 bp)
Type: Others
Protein ID: WP_017449237.1
Location: 90184..90759 (576 bp)
Type: Others
Protein ID: WP_017449240.1
Location: 90759..91490 (732 bp)
Type: Others
Protein ID: WP_023624652.1
Location: 92733..93809 (1077 bp)
Type: Others
Protein ID: WP_122016153.1
Location: 94143..94781 (639 bp)
Type: Others
Protein ID: Protein_108
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D0812_RS2952084686..85690-1005WP_159408506.1Ig-like domain-containing protein-
D0812_RS2952586251..86625-375WP_127914005.1hypothetical protein-
D0812_RS2953086935..87156+222WP_023624649.1hypothetical protein-
D0812_RS2954087759..88142+384Protein_101recombinase family protein-
D0812_RS2954588137..88862-726WP_017449237.1site-specific integrase-
D0812_RS2955089313..89543+231WP_122016154.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
D0812_RS2955589540..89881+342WP_023624650.1endoribonuclease MazFToxin
D0812_RS2956090184..90759-576WP_017449240.1hypothetical protein-
D0812_RS2956590759..91490-732WP_023624652.1AHH domain-containing protein-
D0812_RS2957592733..93809-1077WP_122016153.1replication initiation protein-
D0812_RS2958094143..94781-639Protein_108IS5 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..117926117926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-107)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12159.65 Da        Isoelectric Point: 5.8124

>T113239 WP_023624650.1 NZ_CP033139:89540-89881 [Vibrio owensii]
MTYAVPEKGDVVVMSFNPQSGHEQAGDSRPGLVISPKEFNQATGFALVCPITNQSKGYPFEVEITGSQKTTGVVLADQVK
SLDWRARRARVVDSVSNETLGTVRDYVTAIANG

Download         Length: 342 bp

>T113239 NZ_CP033139:89540-89881 [Vibrio owensii]
ATGACGTATGCAGTACCAGAGAAAGGCGATGTAGTAGTAATGAGTTTTAATCCGCAAAGCGGACACGAACAAGCGGGAGA
CAGTCGGCCTGGGCTGGTCATTTCCCCGAAAGAGTTTAACCAAGCAACTGGCTTTGCTCTGGTATGCCCCATAACCAACC
AGTCAAAAGGATATCCGTTTGAAGTTGAAATAACCGGAAGCCAAAAAACAACGGGTGTGGTGCTGGCTGACCAAGTGAAG
TCCTTGGATTGGCGCGCGCGTCGCGCTCGTGTGGTGGACTCCGTTTCAAACGAAACACTGGGGACTGTGCGGGATTATGT
CACAGCGATTGCTAATGGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8499.87 Da        Isoelectric Point: 6.4604

>AT113239 WP_122016154.1 NZ_CP033139:89313-89543 [Vibrio owensii]
MSQTIAKWGHSAAVRIPSKVLKNMDMAVGDKVEVKVFNRQIIIEPAKPTLAQILSQITDENRHDEVITETMGNELL

Download         Length: 231 bp

>AT113239 NZ_CP033139:89313-89543 [Vibrio owensii]
ATGTCACAAACAATAGCTAAGTGGGGCCACAGCGCAGCTGTGCGTATACCTTCTAAGGTATTGAAAAATATGGATATGGC
GGTGGGTGACAAAGTGGAGGTTAAAGTGTTCAATCGACAAATTATCATTGAACCTGCAAAACCAACACTCGCCCAGATTT
TGAGTCAGATCACTGATGAAAACCGCCATGATGAAGTAATCACCGAAACTATGGGTAATGAATTGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1Y1BA95

Antitoxin

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Source
ID
Structure
No matching records found

References