Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1474256..1474815 Replicon chromosome
Accession NZ_CP033137
Organism Vibrio owensii strain 1700302

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag D0812_RS06930 Protein ID WP_005398411.1
Coordinates 1474256..1474534 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3G2PT85
Locus tag D0812_RS06935 Protein ID WP_054824926.1
Coordinates 1474531..1474815 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0812_RS06905 1470788..1471372 + 585 WP_038896808.1 ribosomal protein S5-alanine N-acetyltransferase -
D0812_RS06910 1471373..1471960 + 588 WP_054824176.1 HD domain-containing protein -
D0812_RS06915 1471974..1472447 + 474 WP_054824177.1 DUF2947 domain-containing protein -
D0812_RS06920 1472506..1473468 - 963 WP_054824178.1 integron integrase -
D0812_RS06930 1474256..1474534 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
D0812_RS06935 1474531..1474815 - 285 WP_054824926.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D0812_RS06940 1474892..1475005 + 114 WP_104047644.1 DUF3265 domain-containing protein -
D0812_RS06945 1475438..1475530 + 93 WP_005445221.1 DUF3265 domain-containing protein -
D0812_RS06950 1475562..1475990 + 429 WP_054824934.1 ester cyclase -
D0812_RS06955 1476005..1476097 + 93 WP_194842408.1 DUF3265 domain-containing protein -
D0812_RS06960 1476201..1476467 + 267 WP_041061928.1 hypothetical protein -
D0812_RS06965 1476471..1476593 + 123 WP_080772516.1 DUF3265 domain-containing protein -
D0812_RS06970 1476634..1477143 + 510 WP_047707023.1 SMI1/KNR4 family protein -
D0812_RS06975 1477174..1477263 + 90 WP_072609598.1 DUF3265 domain-containing protein -
D0812_RS06980 1477301..1478554 + 1254 WP_054824855.1 hypothetical protein -
D0812_RS06985 1478569..1478661 + 93 WP_194842420.1 DUF3265 domain-containing protein -
D0812_RS06990 1478642..1479430 + 789 WP_122044962.1 hypothetical protein -
D0812_RS06995 1479445..1479537 + 93 WP_194842409.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1474256..1526669 52413
- inside Integron - - 1472506..1489622 17116


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T113237 WP_005398411.1 NZ_CP033137:c1474534-1474256 [Vibrio owensii]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T113237 NZ_CP033137:c1474534-1474256 [Vibrio owensii]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGTA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGTGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11000.29 Da        Isoelectric Point: 8.0517

>AT113237 WP_054824926.1 NZ_CP033137:c1474815-1474531 [Vibrio owensii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEESKARIRNRGKQ

Download         Length: 285 bp

>AT113237 NZ_CP033137:c1474815-1474531 [Vibrio owensii]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGAGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A3G2PT85

References