Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 2046785..2047551 Replicon chromosome
Accession NZ_CP033134
Organism Vibrio campbellii strain 170502

Toxin (Protein)


Gene name - Uniprot ID A0A3Q0L5V0
Locus tag D0784_RS09575 Protein ID WP_011080392.1
Coordinates 2047054..2047551 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A3N3DV16
Locus tag D0784_RS09570 Protein ID WP_013571703.1
Coordinates 2046785..2047057 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0784_RS09525 2041829..2042797 + 969 WP_076611895.1 IS30-like element ISVa6 family transposase -
D0784_RS09530 2042823..2043155 - 333 WP_122020202.1 hypothetical protein -
D0784_RS09535 2043170..2043649 - 480 WP_122019790.1 type VI secretion system amidase effector protein Tae4 -
D0784_RS27010 2044338..2044430 - 93 WP_078532186.1 DUF3265 domain-containing protein -
D0784_RS09550 2044545..2045513 + 969 WP_076611895.1 IS30-like element ISVa6 family transposase -
D0784_RS09555 2045539..2046051 - 513 WP_033008070.1 hypothetical protein -
D0784_RS09560 2046080..2046202 - 123 WP_122019791.1 DUF3265 domain-containing protein -
D0784_RS27015 2046583..2046675 - 93 WP_086459316.1 DUF3265 domain-containing protein -
D0784_RS09570 2046785..2047057 + 273 WP_013571703.1 DUF1778 domain-containing protein Antitoxin
D0784_RS09575 2047054..2047551 + 498 WP_011080392.1 GNAT family N-acetyltransferase Toxin
D0784_RS09580 2047585..2047674 - 90 WP_074531738.1 DUF3265 domain-containing protein -
D0784_RS09585 2047716..2048216 - 501 WP_122019792.1 hypothetical protein -
D0784_RS09590 2048265..2048354 - 90 WP_071849711.1 DUF3265 domain-containing protein -
D0784_RS09595 2048451..2049122 + 672 WP_122019793.1 hypothetical protein -
D0784_RS09600 2049171..2049263 - 93 WP_206384590.1 DUF3265 domain-containing protein -
D0784_RS09605 2049378..2050346 + 969 WP_076611895.1 IS30-like element ISVa6 family transposase -
D0784_RS09610 2050372..2051097 - 726 WP_122019794.1 NYN domain-containing protein -
D0784_RS09620 2051342..2052310 + 969 WP_122019796.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1992757..2070280 77523
- inside IScluster/Tn - - 2042021..2052310 10289
- inside Integron - - 2003355..2070280 66925


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18486.13 Da        Isoelectric Point: 8.0487

>T113236 WP_011080392.1 NZ_CP033134:2047054-2047551 [Vibrio campbellii]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFEDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T113236 NZ_CP033134:2047054-2047551 [Vibrio campbellii]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAAAAAGACAACACCAGAACATTTGTTTTGGAAGATGATAACGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAGTTACAAAAAAAACACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATTGACGCACTCAGAAAGCTATTAGCTGCAAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CGAAACACTTCTATGAACGCTATGGTTTTCAAGCATTTGAAGACGCTGAAAATAAACTCTTCATCACCATTGCTGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9747.28 Da        Isoelectric Point: 8.5960

>AT113236 WP_013571703.1 NZ_CP033134:2046785-2047057 [Vibrio campbellii]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKIQ

Download         Length: 273 bp

>AT113236 NZ_CP033134:2046785-2047057 [Vibrio campbellii]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGTATGTCTAGCATCAACTCGTTCGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGACCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5V0

Antitoxin

Source ID Structure
AlphaFold DB A0A3N3DV16

References