Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 2034740..2035289 Replicon chromosome
Accession NZ_CP033134
Organism Vibrio campbellii strain 170502

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag D0784_RS09440 Protein ID WP_122019780.1
Coordinates 2034990..2035289 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag D0784_RS09435 Protein ID WP_122019779.1
Coordinates 2034740..2034982 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0784_RS09380 2029883..2030173 + 291 WP_047010341.1 type II toxin-antitoxin system RelE/ParE family toxin -
D0784_RS09385 2030192..2030284 - 93 WP_080102040.1 DUF3265 domain-containing protein -
D0784_RS09390 2030299..2030613 - 315 WP_017049537.1 DNA-binding transcriptional regulator -
D0784_RS09395 2030600..2030932 - 333 WP_012600340.1 type II toxin-antitoxin system RelE/ParE family toxin -
D0784_RS09400 2031035..2031127 - 93 Protein_1780 DUF3265 domain-containing protein -
D0784_RS09405 2031157..2031798 - 642 WP_122019776.1 hypothetical protein -
D0784_RS09415 2032858..2032990 - 133 Protein_1782 DUF3265 domain-containing protein -
D0784_RS09425 2033479..2033571 - 93 WP_193244088.1 DUF3265 domain-containing protein -
D0784_RS09430 2033598..2034506 - 909 WP_122019778.1 phosphotransferase -
D0784_RS09435 2034740..2034982 + 243 WP_122019779.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0784_RS09440 2034990..2035289 + 300 WP_122019780.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0784_RS09445 2035353..2035445 - 93 WP_079765077.1 DUF3265 domain-containing protein -
D0784_RS09450 2035460..2036233 - 774 WP_122019781.1 NERD domain-containing protein -
D0784_RS09455 2036371..2037000 - 630 WP_122019782.1 type B chloramphenicol O-acetyltransferase -
D0784_RS09460 2037057..2037908 - 852 WP_162998985.1 IS3 family transposase -
D0784_RS09465 2037992..2038213 - 222 Protein_1791 transposase -
D0784_RS09470 2038295..2038384 - 90 WP_206384589.1 DUF3265 domain-containing protein -
D0784_RS09475 2038411..2038791 - 381 WP_122019783.1 DUF4087 domain-containing protein -
D0784_RS09480 2038819..2038911 - 93 WP_077681052.1 DUF3265 domain-containing protein -
D0784_RS09485 2038926..2039552 - 627 WP_162998986.1 hypothetical protein -
D0784_RS27005 2039597..2039686 - 90 WP_079379794.1 DUF3265 domain-containing protein -
D0784_RS09495 2039713..2040072 - 360 WP_122019786.1 hypothetical protein -
D0784_RS09500 2040092..2040181 - 90 WP_122020200.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1992757..2070280 77523
- inside Integron - - 2003355..2070280 66925


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11475.08 Da        Isoelectric Point: 9.3224

>T113235 WP_122019780.1 NZ_CP033134:2034990-2035289 [Vibrio campbellii]
MQKNKYKLSNLAQSHLRKVKSYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T113235 NZ_CP033134:2034990-2035289 [Vibrio campbellii]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGTAAAAAGCTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGTAACTACAAAGATACTCTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGGCTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTCCCGATTGGCAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTCTTAGGTCAATCACAGCTACCTCAGAATCATCTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9133.39 Da        Isoelectric Point: 5.7121

>AT113235 WP_122019779.1 NZ_CP033134:2034740-2034982 [Vibrio campbellii]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNEKTVDGESFLNSL

Download         Length: 243 bp

>AT113235 NZ_CP033134:2034740-2034982 [Vibrio campbellii]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTGAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGAAAAAACTGTTGATGGCGAAAGCTTTCTGAACTCGCTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References