Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2029645..2030173 Replicon chromosome
Accession NZ_CP033134
Organism Vibrio campbellii strain 170502

Toxin (Protein)


Gene name relE Uniprot ID A0A2N7HV18
Locus tag D0784_RS09380 Protein ID WP_047010341.1
Coordinates 2029883..2030173 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag D0784_RS09375 Protein ID WP_005377003.1
Coordinates 2029645..2029893 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0784_RS09330 2025017..2025106 - 90 WP_072606010.1 DUF3265 domain-containing protein -
D0784_RS09340 2025627..2025719 - 93 WP_206384574.1 DUF3265 domain-containing protein -
D0784_RS09345 2025743..2026447 - 705 WP_122019774.1 hypothetical protein -
D0784_RS09350 2026687..2027118 - 432 WP_122019775.1 GNAT family N-acetyltransferase -
D0784_RS09355 2027217..2027306 - 90 WP_072606010.1 DUF3265 domain-containing protein -
D0784_RS09360 2027837..2027929 - 93 WP_077681847.1 DUF3265 domain-containing protein -
D0784_RS09365 2028384..2028476 - 93 WP_196298091.1 DUF3265 domain-containing protein -
D0784_RS09370 2028591..2029559 + 969 WP_076611895.1 IS30-like element ISVa6 family transposase -
D0784_RS09375 2029645..2029893 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0784_RS09380 2029883..2030173 + 291 WP_047010341.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0784_RS09385 2030192..2030284 - 93 WP_080102040.1 DUF3265 domain-containing protein -
D0784_RS09390 2030299..2030613 - 315 WP_017049537.1 DNA-binding transcriptional regulator -
D0784_RS09395 2030600..2030932 - 333 WP_012600340.1 type II toxin-antitoxin system RelE/ParE family toxin -
D0784_RS09400 2031035..2031127 - 93 Protein_1780 DUF3265 domain-containing protein -
D0784_RS09405 2031157..2031798 - 642 WP_122019776.1 hypothetical protein -
D0784_RS09415 2032858..2032990 - 133 Protein_1782 DUF3265 domain-containing protein -
D0784_RS09425 2033479..2033571 - 93 WP_193244088.1 DUF3265 domain-containing protein -
D0784_RS09430 2033598..2034506 - 909 WP_122019778.1 phosphotransferase -
D0784_RS09435 2034740..2034982 + 243 WP_122019779.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1992757..2070280 77523
- flank IS/Tn - - 2028783..2029559 776
- inside Integron - - 2003355..2070280 66925


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11275.28 Da        Isoelectric Point: 10.5932

>T113233 WP_047010341.1 NZ_CP033134:2029883-2030173 [Vibrio campbellii]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDIIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T113233 NZ_CP033134:2029883-2030173 [Vibrio campbellii]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATATCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT113233 WP_005377003.1 NZ_CP033134:2029645-2029893 [Vibrio campbellii]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT113233 NZ_CP033134:2029645-2029893 [Vibrio campbellii]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCCTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N7HV18

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References