Detailed information of TA system TA113232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 2021415..2021980
• Replicon: chromosome
• Accession: NZ_CP033134
• Organism: Vibrio campbellii strain 170502

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D0784_RS09290
• Protein ID: WP_122019772.1
• Coordinates: 2021415..2021702 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: D0784_RS09295
• Protein ID: WP_000086647.1
• Coordinates: 2021699..2021980 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0784_RS09245	2017566..2017658	-	93	WP_206384588.1	DUF3265 domain-containing protein	-
D0784_RS09250	2017978..2018232	-	255	Protein_1754	hypothetical protein	-
D0784_RS09255	2018242..2018742	-	501	WP_122019768.1	hypothetical protein	-
D0784_RS09260	2018911..2019003	-	93	WP_081641279.1	DUF3265 domain-containing protein	-
D0784_RS09265	2019078..2019323	+	246	WP_038140558.1	type II toxin-antitoxin system CcdA family antitoxin	-
D0784_RS09270	2019323..2019640	+	318	WP_122019770.1	CcdB family protein	-
D0784_RS09275	2019931..2020173	-	243	WP_122019771.1	NUDIX domain-containing protein	-
D0784_RS09280	2020201..2020293	-	93	WP_206384572.1	DUF3265 domain-containing protein	-
D0784_RS09285	2020408..2021376	+	969	WP_076611895.1	IS30-like element ISVa6 family transposase	-
D0784_RS09290	2021415..2021702	-	288	WP_122019772.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0784_RS09295	2021699..2021980	-	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D0784_RS09300	2022093..2022944	-	852	WP_162998985.1	IS3 family transposase	-
D0784_RS09305	2023028..2023249	-	222	Protein_1765	transposase	-
D0784_RS09310	2023820..2023951	-	132	WP_080637474.1	DUF3265 domain-containing protein	-
D0784_RS09330	2025017..2025106	-	90	WP_072606010.1	DUF3265 domain-containing protein	-
D0784_RS09340	2025627..2025719	-	93	WP_206384574.1	DUF3265 domain-containing protein	-
D0784_RS09345	2025743..2026447	-	705	WP_122019774.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1992757..2070280	77523
	-	inside	IScluster/Tn	-	-	2012639..2021376	8737
	-	inside	Integron	-	-	2003355..2070280	66925

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10985.65 Da
• Isoelectric Point: 5.1098

>T113232 WP_122019772.1 NZ_CP033134:c2021702-2021415 [Vibrio campbellii]
MKVVWSPLALQKLGDAAEFISLDNPPAAEKWVNEVFDKTELLGSMPEIGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T113232 NZ_CP033134:c2021702-2021415 [Vibrio campbellii]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
GGCAGAGAAGTGGGTAAACGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATTGGGCGGTTTGTTCCTG
AAATGCCCCATACGAATTATCGTGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATTCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT113232 WP_000086647.1 NZ_CP033134:c2021980-2021699 [Vibrio campbellii]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT113232 NZ_CP033134:c2021980-2021699 [Vibrio campbellii]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0