Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2014913..2015441 Replicon chromosome
Accession NZ_CP033134
Organism Vibrio campbellii strain 170502

Toxin (Protein)


Gene name relE Uniprot ID A0A2N7HV18
Locus tag D0784_RS09225 Protein ID WP_047010341.1
Coordinates 2015151..2015441 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag D0784_RS09220 Protein ID WP_005377003.1
Coordinates 2014913..2015161 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0784_RS09180 2009937..2010572 - 636 WP_122019763.1 hypothetical protein -
D0784_RS09185 2010688..2010780 - 93 WP_072884142.1 DUF3265 domain-containing protein -
D0784_RS09190 2010805..2012145 - 1341 WP_122019764.1 Fic family protein -
D0784_RS09200 2012447..2013415 + 969 WP_076611895.1 IS30-like element ISVa6 family transposase -
D0784_RS09205 2013457..2014128 - 672 WP_122019766.1 hypothetical protein -
D0784_RS09210 2014157..2014273 - 117 WP_122020196.1 DUF3265 domain-containing protein -
D0784_RS09215 2014264..2014716 - 453 WP_009704196.1 hypothetical protein -
D0784_RS27000 2014770..2014838 - 69 WP_074531725.1 DUF3265 domain-containing protein -
D0784_RS09220 2014913..2015161 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0784_RS09225 2015151..2015441 + 291 WP_047010341.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0784_RS09235 2016008..2016100 - 93 WP_196298091.1 DUF3265 domain-containing protein -
D0784_RS09240 2016215..2017183 + 969 WP_076611895.1 IS30-like element ISVa6 family transposase -
D0784_RS09245 2017566..2017658 - 93 WP_206384588.1 DUF3265 domain-containing protein -
D0784_RS09250 2017978..2018232 - 255 Protein_1754 hypothetical protein -
D0784_RS09255 2018242..2018742 - 501 WP_122019768.1 hypothetical protein -
D0784_RS09260 2018911..2019003 - 93 WP_081641279.1 DUF3265 domain-containing protein -
D0784_RS09265 2019078..2019323 + 246 WP_038140558.1 type II toxin-antitoxin system CcdA family antitoxin -
D0784_RS09270 2019323..2019640 + 318 WP_122019770.1 CcdB family protein -
D0784_RS09275 2019931..2020173 - 243 WP_122019771.1 NUDIX domain-containing protein -
D0784_RS09280 2020201..2020293 - 93 WP_206384572.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1992757..2070280 77523
- inside IScluster/Tn - - 2012639..2021376 8737
- inside Integron - - 2003355..2070280 66925


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11275.28 Da        Isoelectric Point: 10.5932

>T113231 WP_047010341.1 NZ_CP033134:2015151-2015441 [Vibrio campbellii]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDIIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T113231 NZ_CP033134:2015151-2015441 [Vibrio campbellii]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATATCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT113231 WP_005377003.1 NZ_CP033134:2014913-2015161 [Vibrio campbellii]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT113231 NZ_CP033134:2014913-2015161 [Vibrio campbellii]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCCTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N7HV18

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References