Detailed information of TA system TA113230

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2006377..2006924
• Replicon: chromosome
• Accession: NZ_CP033134
• Organism: Vibrio campbellii strain 170502

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D0784_RS09140
• Protein ID: WP_103196285.1
• Coordinates: 2006377..2006679 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: D0784_RS09145
• Protein ID: WP_005448240.1
• Coordinates: 2006667..2006924 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0784_RS09100	2001658..2001834	-	177	WP_122020194.1	DUF3265 domain-containing protein	-
D0784_RS09105	2001865..2002833	+	969	WP_076611895.1	IS30-like element ISVa6 family transposase	-
D0784_RS09110	2002870..2003358	-	489	WP_038882469.1	hypothetical protein	-
D0784_RS09115	2003355..2003807	-	453	WP_025543425.1	hypothetical protein	-
D0784_RS09120	2004032..2004487	-	456	WP_122019759.1	NUDIX domain-containing protein	-
D0784_RS09125	2004540..2004629	-	90	WP_206384585.1	DUF3265 domain-containing protein	-
D0784_RS09130	2004747..2005715	+	969	WP_076611895.1	IS30-like element ISVa6 family transposase	-
D0784_RS09140	2006377..2006679	-	303	WP_103196285.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0784_RS09145	2006667..2006924	-	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D0784_RS09150	2007006..2007095	-	90	WP_075111252.1	DUF3265 domain-containing protein	-
D0784_RS26995	2007616..2007705	-	90	WP_079765096.1	DUF3265 domain-containing protein	-
D0784_RS09160	2007734..2008192	-	459	WP_069218289.1	GNAT family N-acetyltransferase	-
D0784_RS09165	2008246..2009097	-	852	WP_162998985.1	IS3 family transposase	-
D0784_RS09170	2009181..2009402	-	222	Protein_1739	transposase	-
D0784_RS09175	2009605..2009937	-	333	WP_017191334.1	hypothetical protein	-
D0784_RS09180	2009937..2010572	-	636	WP_122019763.1	hypothetical protein	-
D0784_RS09185	2010688..2010780	-	93	WP_072884142.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1992757..2070280	77523
	-	inside	Integron	-	-	2003355..2070280	66925

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11669.57 Da
• Isoelectric Point: 5.1765

>T113230 WP_103196285.1 NZ_CP033134:c2006679-2006377 [Vibrio campbellii]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDADKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T113230 NZ_CP033134:c2006679-2006377 [Vibrio campbellii]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATATATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACGTTCCCGGAGTCAGGTCGTATTCCAC
CTGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGCGTTTTCTATAAACAAGACGCTGACAAGGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT113230 WP_005448240.1 NZ_CP033134:c2006924-2006667 [Vibrio campbellii]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT113230 NZ_CP033134:c2006924-2006667 [Vibrio campbellii]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACTAAAGAACCCGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8