Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 860505..860982 Replicon chromosome
Accession NZ_CP033114
Organism Staphylococcus aureus strain ST20130945

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAST45_RS04030 Protein ID WP_000052076.1
Coordinates 860505..860693 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAST45_RS04035 Protein ID WP_001059690.1
Coordinates 860722..860982 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST45_RS04000 856458..857015 + 558 WP_000824491.1 hypothetical protein -
SAST45_RS04005 857356..858042 + 687 WP_001574556.1 thermonuclease family protein -
SAST45_RS04010 858399..858599 + 201 WP_001059082.1 cold-shock protein -
SAST45_RS04015 859096..859314 - 219 WP_000005879.1 hypothetical protein -
SAST45_RS04020 859376..859660 - 285 WP_001004401.1 hypothetical protein -
SAST45_RS04025 859748..860317 - 570 WP_001106663.1 hypothetical protein -
SAST45_RS04030 860505..860693 - 189 WP_000052076.1 hypothetical protein Toxin
SAST45_RS04035 860722..860982 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAST45_RS04040 861323..861526 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAST45_RS04045 861523..861761 - 239 Protein_785 hypothetical protein -
SAST45_RS04050 861986..862567 + 582 WP_196492359.1 phosphoglycerate mutase family protein -
SAST45_RS04055 862640..863257 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
SAST45_RS04060 863413..863907 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAST45_RS04065 864306..864728 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SAST45_RS04070 864876..865592 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T113206 WP_000052076.1 NZ_CP033114:c860693-860505 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T113206 NZ_CP033114:c860693-860505 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT113206 WP_001059690.1 NZ_CP033114:c860982-860722 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT113206 NZ_CP033114:c860982-860722 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References