Detailed information of TA system TA113200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2242504..2243018
• Replicon: chromosome
• Accession: NZ_CP033112
• Organism: Staphylococcus aureus strain ST20130944

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: SAST44_RS11160
• Protein ID: WP_155682278.1
• Coordinates: 2242504..2242713 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A0D1GBN9
• Locus tag: SAST44_RS11165
• Protein ID: WP_000138934.1
• Coordinates: 2242725..2243018 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAST44_RS11140	2238393..2239463	-	1071	WP_000159639.1	D-alanine--D-alanine ligase	-
SAST44_RS11145	2239781..2240983	+	1203	WP_001109939.1	rod shape-determining protein RodA	-
SAST44_RS11150	2241144..2241827	-	684	Protein_2155	transposase	-
SAST44_RS11155	2242239..2242376	-	138	WP_000828354.1	hypothetical protein	-
SAST44_RS11160	2242504..2242713	-	210	WP_155682278.1	heavy-metal-associated domain-containing protein	Toxin
SAST44_RS11165	2242725..2243018	-	294	WP_000138934.1	copper-sensing transcriptional repressor CsoR	Antitoxin
SAST44_RS11170	2243184..2244668	+	1485	WP_000571560.1	cardiolipin synthase	-
SAST44_RS11175	2244696..2245343	+	648	WP_001187612.1	HD domain-containing protein	-
SAST44_RS14485	2245500..2245799	+	300	WP_001793952.1	hypothetical protein	-
SAST44_RS11185	2245956..2246828	-	873	WP_000725802.1	membrane protein insertase YidC	-
SAST44_RS11190	2246914..2247555	-	642	WP_000483150.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7796.80 Da
• Isoelectric Point: 4.1008

>T113200 WP_155682278.1 NZ_CP033112:c2242713-2242504 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYEAPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T113200 NZ_CP033112:c2242713-2242504 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGGCACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11185.77 Da
• Isoelectric Point: 6.2243

>AT113200 WP_000138934.1 NZ_CP033112:c2243018-2242725 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT113200 NZ_CP033112:c2243018-2242725 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D1GBN9