Detailed information of TA system TA113184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1913332..1914968
• Replicon: chromosome
• Accession: NZ_CP033108
• Organism: Acinetobacter baumannii ATCC 17978

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1E3M7C1
• Locus tag: EAE94_RS09125
• Protein ID: WP_000737056.1
• Coordinates: 1913332..1914663 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: EAE94_RS09130
• Protein ID: WP_001101308.1
• Coordinates: 1914660..1914968 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAE94_RS09105 (EAE94_09135)	1909647..1910807	+	1161	WP_001044492.1	hypothetical protein	-
EAE94_RS09110 (EAE94_09140)	1910934..1911905	+	972	WP_109104914.1	5'/3'-nucleotidase SurE	-
EAE94_RS09115 (EAE94_09145)	1911917..1912561	+	645	WP_000817301.1	hypothetical protein	-
EAE94_RS09120 (EAE94_09150)	1912596..1913036	-	441	WP_000193135.1	HD domain-containing protein	-
EAE94_RS09125 (EAE94_09155)	1913332..1914663	+	1332	WP_000737056.1	HipA domain-containing protein	Toxin
EAE94_RS09130 (EAE94_09160)	1914660..1914968	+	309	WP_001101308.1	helix-turn-helix domain-containing protein	Antitoxin
EAE94_RS09135 (EAE94_09170)	1915694..1916245	+	552	WP_049594830.1	TetR/AcrR family transcriptional regulator	-
EAE94_RS09140 (EAE94_09175)	1916461..1917081	+	621	WP_000658761.1	hypothetical protein	-
EAE94_RS09145 (EAE94_09180)	1917099..1918181	+	1083	WP_001095788.1	XRE family transcriptional regulator	-
EAE94_RS09150 (EAE94_09185)	1918223..1918738	+	516	WP_000914805.1	hypothetical protein	-
EAE94_RS09155 (EAE94_09190)	1918886..1919404	+	519	WP_000651611.1	GNAT family N-acetyltransferase	-
EAE94_RS09160	1919385..1919516	+	132	Protein_1781	TetR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.16 Da
• Isoelectric Point: 4.7456

>T113184 WP_000737056.1 NZ_CP033108:1913332-1914663 [Acinetobacter baumannii ATCC 17978]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T113184 NZ_CP033108:1913332-1914663 [Acinetobacter baumannii ATCC 17978]
ATGAAAAAATTAACGATACAAGCTTTACTAAATAAAAACTGGATAGATATAGCAGAGCTAAAACTGTTAGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAATATGAATTGGATTATGCAATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACACGAATCGGATACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTGGTGGTGCAACTGGTGCAGGCGGTGAAGCTCCCAAGTTGCTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGA
CACCTACCAAGAACAATTTGATCAGCCAGATCAGCATTATTTAGTTAAATTTCCGCGAAATAATCGTAGCGAGATTGATT
GCGATATTCTCAGAGCTGAATATTATTACTATCAAATACTCAATGAGTTAGGTTTCAATACGATAGAGACGACTCAAATG
CAGCTTATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTATTTGTGAGTGGTTACAACGCGACTTACTC
AATATCATTTTTGGCAATTCAGATAACCACGGTCGGAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCAGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTATGAGGAAG
GAGGTGAATACCGGTGGGCACAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCAACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCAAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11626.55 Da
• Isoelectric Point: 9.9701

>AT113184 WP_001101308.1 NZ_CP033108:1914660-1914968 [Acinetobacter baumannii ATCC 17978]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT113184 NZ_CP033108:1914660-1914968 [Acinetobacter baumannii ATCC 17978]
ATGAATGTAAAAAATCAACCCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTATCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAACCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Structures

Toxin

• AlphaFold DB: A0A1E3M7C1