Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 457402..458055 Replicon chromosome
Accession NZ_CP033108
Organism Acinetobacter baumannii ATCC 17978

Toxin (Protein)


Gene name cptA Uniprot ID A0A1E3M967
Locus tag EAE94_RS02245 Protein ID WP_009518132.1
Coordinates 457666..458055 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag EAE94_RS02240 Protein ID WP_001288210.1
Coordinates 457402..457659 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAE94_RS02220 (EAE94_02235) 452917..453924 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
EAE94_RS02225 (EAE94_02240) 453943..454320 + 378 WP_001216380.1 50S ribosomal protein L17 -
EAE94_RS02230 (EAE94_02245) 454502..455992 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
EAE94_RS02235 (EAE94_02250) 456042..457214 - 1173 WP_001190550.1 acyl-CoA dehydrogenase family protein -
EAE94_RS02240 (EAE94_02255) 457402..457659 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
EAE94_RS02245 (EAE94_02260) 457666..458055 + 390 WP_009518132.1 hypothetical protein Toxin
EAE94_RS02250 (EAE94_02265) 458825..459910 + 1086 WP_000049106.1 hypothetical protein -
EAE94_RS02255 (EAE94_02270) 459989..460555 + 567 WP_000651535.1 rhombosortase -
EAE94_RS02260 (EAE94_02275) 460743..462938 + 2196 WP_001158904.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15720.03 Da        Isoelectric Point: 10.4623

>T113182 WP_009518132.1 NZ_CP033108:457666-458055 [Acinetobacter baumannii ATCC 17978]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Download         Length: 390 bp

>T113182 NZ_CP033108:457666-458055 [Acinetobacter baumannii ATCC 17978]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAACTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAACAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT113182 WP_001288210.1 NZ_CP033108:457402-457659 [Acinetobacter baumannii ATCC 17978]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT113182 NZ_CP033108:457402-457659 [Acinetobacter baumannii ATCC 17978]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M967

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References