Detailed information of TA system TA113177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2364796..2365375
• Replicon: chromosome
• Accession: NZ_CP033106
• Organism: Pantoea sp. 201603H

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EAE31_RS18930
• Protein ID: WP_195761688.1
• Coordinates: 2365250..2365375 (-)
• Length: 42 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EAE31_RS10725
• Protein ID: WP_154325059.1
• Coordinates: 2364796..2365203 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAE31_RS10685	2361071..2361520	-	450	WP_154325052.1	DUF2280 domain-containing protein	-
EAE31_RS10690	2361551..2362189	-	639	WP_154325053.1	hypothetical protein	-
EAE31_RS10695	2362198..2362392	-	195	WP_154325054.1	hypothetical protein	-
EAE31_RS10700	2362389..2362583	-	195	WP_154325055.1	hypothetical protein	-
EAE31_RS10705	2362737..2363336	-	600	WP_154325056.1	Rha family transcriptional regulator	-
EAE31_RS10710	2363452..2363925	-	474	WP_154325057.1	lysis protein	-
EAE31_RS10715	2363906..2364418	-	513	WP_154325058.1	lysozyme	-
EAE31_RS10720	2364420..2364665	-	246	WP_195761736.1	class II holin family protein	-
EAE31_RS10725	2364796..2365203	-	408	WP_154325059.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EAE31_RS18930	2365250..2365375	-	126	WP_195761688.1	mRNA interferase	Toxin
EAE31_RS10730	2365584..2366114	-	531	WP_154325060.1	antiterminator	-
EAE31_RS10735	2366095..2366229	-	135	WP_154325061.1	YlcG family protein	-
EAE31_RS10740	2366226..2366849	-	624	WP_154325062.1	recombination protein NinG	-
EAE31_RS10745	2366842..2367144	-	303	WP_195761737.1	hypothetical protein	-
EAE31_RS10750	2367259..2367459	-	201	WP_154325064.1	hypothetical protein	-
EAE31_RS10755	2367739..2368173	-	435	WP_154325065.1	recombination protein NinB	-
EAE31_RS10760	2368472..2369323	-	852	WP_154325066.1	ATP-binding protein	-
EAE31_RS10765	2369333..2370211	-	879	WP_154325067.1	replication protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2328452..2388823	60371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-109)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4764.49 Da
• Isoelectric Point: 11.6500

>T113177 WP_195761688.1 NZ_CP033106:c2365375-2365250 [Pantoea sp. 201603H]
VKQSEFRRWLAAQGAEFKDGTNHLKIFLNGRQTIMPRHPGK

Nucleotide

• Length: 126 bp

>T113177 NZ_CP033106:c2365375-2365250 [Pantoea sp. 201603H]
GTGAAGCAAAGCGAGTTCAGGCGTTGGCTTGCGGCTCAGGGGGCAGAATTTAAAGACGGCACAAACCATCTGAAAATTTT
CCTCAACGGCAGGCAGACGATAATGCCGAGGCATCCGGGGAAATAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14762.86 Da
• Isoelectric Point: 4.3325

>AT113177 WP_154325059.1 NZ_CP033106:c2365203-2364796 [Pantoea sp. 201603H]
MRYPVTFDCDETGCAVFFPDIPEAMTGSDTREEALAMAQDALVTALDFYFEDRRLIPEPSVNGEEFIEVPASVAAKVLLL
NAVVNAGITNAELARLTGTRPQEVTRILDLHHSTKIDTIQTALKALGKRLELSAL

Nucleotide

• Length: 408 bp

>AT113177 NZ_CP033106:c2365203-2364796 [Pantoea sp. 201603H]
ATGCGTTATCCAGTAACGTTTGATTGTGATGAAACCGGATGTGCGGTGTTTTTCCCCGACATCCCGGAGGCTATGACGGG
CAGTGATACCAGAGAAGAAGCGTTAGCAATGGCGCAGGACGCTCTGGTAACTGCGCTGGACTTCTATTTTGAAGACCGGA
GACTAATTCCCGAGCCATCGGTAAATGGTGAAGAGTTTATTGAGGTTCCAGCCAGCGTGGCGGCTAAAGTGCTGCTGCTT
AATGCGGTTGTTAACGCGGGTATAACTAACGCTGAACTTGCCCGGTTAACAGGCACGCGACCACAGGAAGTGACCAGGAT
CCTCGACCTTCATCACTCAACAAAAATAGATACTATCCAGACGGCGCTAAAGGCGCTTGGTAAGCGGCTGGAGCTTTCCG
CGCTCTGA