Detailed information of TA system TA113176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2273639..2274225
• Replicon: chromosome
• Accession: NZ_CP033106
• Organism: Pantoea sp. 201603H

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EAE31_RS10255
• Protein ID: WP_128176612.1
• Coordinates: 2273639..2273944 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EAE31_RS10260
• Protein ID: WP_128176614.1
• Coordinates: 2273941..2274225 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAE31_RS10220	2268688..2269194	-	507	WP_154324994.1	hypothetical protein	-
EAE31_RS10225	2269194..2269790	-	597	WP_154324995.1	hypothetical protein	-
EAE31_RS10230	2269914..2270594	-	681	WP_154325577.1	hypothetical protein	-
EAE31_RS10235	2270866..2271360	-	495	WP_154324996.1	DUF2569 domain-containing protein	-
EAE31_RS10240	2272019..2272387	+	369	WP_154324997.1	SymE family type I addiction module toxin	-
EAE31_RS10245	2272403..2272789	-	387	WP_154324998.1	hypothetical protein	-
EAE31_RS10250	2272786..2273387	-	602	Protein_2000	ShlA/HecA/FhaA protein	-
EAE31_RS10255	2273639..2273944	-	306	WP_128176612.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EAE31_RS10260	2273941..2274225	-	285	WP_128176614.1	damage-inducible protein J	Antitoxin
EAE31_RS10265	2274197..2274472	-	276	Protein_2003	tyrosine-type recombinase/integrase	-
EAE31_RS10270	2274706..2274896	-	191	Protein_2004	transposase	-
EAE31_RS10275	2275145..2275411	+	267	WP_154325578.1	SymE family type I addiction module toxin	-
EAE31_RS10280	2275458..2275892	-	435	WP_154324999.1	hypothetical protein	-
EAE31_RS18920	2275896..2276168	-	273	WP_195761734.1	toxin C-terminal domain-containing protein	-
EAE31_RS10290	2276607..2277982	-	1376	Protein_2008	VENN motif pre-toxin domain-containing protein	-
EAE31_RS10295	2278085..2278363	+	279	WP_154325000.1	SymE family type I addiction module toxin	-
EAE31_RS10300	2278412..2278912	-	501	WP_154325001.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2268688..2294512	25824

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11468.33 Da
• Isoelectric Point: 10.7853

>T113176 WP_128176612.1 NZ_CP033106:c2273944-2273639 [Pantoea sp. 201603H]
VTSDVQWEIRARADREAIFRYLYQEAGLPVASATDDKLVSMVSILRENPLAGVKAGRTAKQRKLVVPHFPFIIVYVAEET
VVRILRVLHTSRKVASRYSRS

Nucleotide

• Length: 306 bp

>T113176 NZ_CP033106:c2273944-2273639 [Pantoea sp. 201603H]
GTGACATCAGACGTCCAGTGGGAAATACGGGCACGGGCAGACCGAGAGGCTATCTTCCGCTATTTATATCAGGAAGCGGG
CCTGCCGGTCGCCAGCGCGACAGATGATAAGCTCGTCAGTATGGTGAGTATCCTCAGGGAAAACCCACTGGCAGGCGTTA
AAGCCGGGAGAACAGCAAAACAGCGTAAACTGGTTGTTCCCCACTTCCCGTTCATTATCGTCTATGTAGCGGAAGAAACA
GTGGTTCGTATCCTGCGGGTTCTGCATACATCCCGGAAAGTCGCAAGCCGTTACAGCAGAAGTTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10975.18 Da
• Isoelectric Point: 4.6133

>AT113176 WP_128176614.1 NZ_CP033106:c2274225-2273941 [Pantoea sp. 201603H]
MSTIHFRIDDETKRLAMQAAERQKMSLTELMRQRAEELAAEERQYQDGEHDAWLEQQIALAFNRYDAGESQFISNDEMNS
HMDELKAQAARGKL

Nucleotide

• Length: 285 bp

>AT113176 NZ_CP033106:c2274225-2273941 [Pantoea sp. 201603H]
ATGAGCACGATCCACTTCAGAATAGATGATGAAACAAAACGGCTGGCGATGCAGGCAGCAGAGCGCCAGAAGATGAGCCT
GACAGAACTCATGCGCCAGCGGGCTGAAGAACTGGCAGCAGAAGAACGACAGTATCAGGATGGTGAACATGATGCCTGGC
TGGAGCAGCAGATAGCCCTGGCGTTCAATCGCTATGATGCAGGTGAAAGCCAGTTCATCAGTAATGACGAAATGAACAGC
CATATGGATGAACTGAAAGCGCAGGCAGCGCGGGGCAAGCTGTGA