Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 241635..242161 Replicon plasmid pEHZJ1
Accession NZ_CP033103
Organism Enterobacter hormaechei strain L51

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag D8768_RS25530 Protein ID WP_000323025.1
Coordinates 241635..241922 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag D8768_RS25535 Protein ID WP_000534858.1
Coordinates 241922..242161 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8768_RS26300 237205..237381 - 177 WP_001371930.1 hypothetical protein -
D8768_RS25500 237892..238836 + 945 WP_000778029.1 DUF5417 domain-containing protein -
D8768_RS25505 238932..239534 + 603 WP_012695474.1 hypothetical protein -
D8768_RS25510 239594..239944 + 351 WP_000743059.1 hypothetical protein -
D8768_RS25515 239991..240194 + 204 WP_001015183.1 hypothetical protein -
D8768_RS25520 240476..240796 + 321 WP_000332796.1 hypothetical protein -
D8768_RS25525 241405..241563 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
D8768_RS25530 241635..241922 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
D8768_RS25535 241922..242161 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
D8768_RS25545 242424..243347 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
D8768_RS25550 243547..244119 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
D8768_RS25555 244595..245833 - 1239 WP_000219087.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / blaTEM-1B / dfrA19 / blaIMP-26 / qacE / sul1 / fosA5 / tet(D) / catA2 / blaSHV-12 / blaDHA-1 / qnrB4 / ere(A) / aac(6')-IIc mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA 1..343918 343918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T113159 WP_000323025.1 NZ_CP033103:c241922-241635 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T113159 NZ_CP033103:c241922-241635 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT113159 WP_000534858.1 NZ_CP033103:c242161-241922 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT113159 NZ_CP033103:c242161-241922 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References