Detailed information of TA system TA113157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4935029..4935645
• Replicon: chromosome
• Accession: NZ_CP033102
• Organism: Enterobacter hormaechei strain L51

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D8768_RS23890
• Protein ID: WP_080336832.1
• Coordinates: 4935029..4935400 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6G4MTK3
• Locus tag: D8768_RS23895
• Protein ID: WP_015569912.1
• Coordinates: 4935403..4935645 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8768_RS23875	4932529..4933431	+	903	WP_003861960.1	formate dehydrogenase subunit beta	-
D8768_RS23880	4933428..4934063	+	636	WP_006808711.1	formate dehydrogenase cytochrome b556 subunit	-
D8768_RS23885	4934060..4934989	+	930	WP_157508586.1	formate dehydrogenase accessory protein FdhE	-
D8768_RS23890	4935029..4935400	-	372	WP_080336832.1	type II toxin-antitoxin system VapC family toxin	Toxin
D8768_RS23895	4935403..4935645	-	243	WP_015569912.1	ribbon-helix-helix domain-containing protein	Antitoxin
D8768_RS23900	4935844..4936764	+	921	WP_157508587.1	alpha/beta hydrolase	-
D8768_RS23905	4936773..4937714	-	942	WP_022649838.1	fatty acid biosynthesis protein FabY	-
D8768_RS23910	4937759..4938196	-	438	WP_015569909.1	D-tyrosyl-tRNA(Tyr) deacylase	-
D8768_RS23915	4938193..4939074	-	882	WP_023298923.1	virulence factor BrkB family protein	-
D8768_RS23920	4939068..4939667	-	600	WP_023305109.1	glucose-1-phosphatase	-
D8768_RS23925	4939786..4940586	-	801	WP_023298924.1	DeoR/GlpR family DNA-binding transcription regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13737.88 Da
• Isoelectric Point: 6.4882

>T113157 WP_080336832.1 NZ_CP033102:c4935400-4935029 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQL

Nucleotide

• Length: 372 bp

>T113157 NZ_CP033102:c4935400-4935029 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9440.72 Da
• Isoelectric Point: 4.4076

>AT113157 WP_015569912.1 NZ_CP033102:c4935645-4935403 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT113157 NZ_CP033102:c4935645-4935403 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGTAAGTTGCGTGAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A6G4MTK3