Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3851149..3851770 Replicon chromosome
Accession NZ_CP033102
Organism Enterobacter hormaechei strain L51

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag D8768_RS18740 Protein ID WP_015571250.1
Coordinates 3851552..3851770 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag D8768_RS18735 Protein ID WP_006809850.1
Coordinates 3851149..3851523 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8768_RS18725 3846277..3847470 + 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
D8768_RS18730 3847493..3850639 + 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
D8768_RS18735 3851149..3851523 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
D8768_RS18740 3851552..3851770 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
D8768_RS18745 3851978..3852529 + 552 WP_023305596.1 maltose O-acetyltransferase -
D8768_RS18750 3852646..3853113 + 468 WP_022647269.1 hypothetical protein -
D8768_RS18755 3853085..3854545 - 1461 WP_157508291.1 PLP-dependent aminotransferase family protein -
D8768_RS18760 3854648..3855358 + 711 WP_157508293.1 GNAT family N-acetyltransferase -
D8768_RS18765 3855355..3855495 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
D8768_RS18770 3855498..3855758 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T113156 WP_015571250.1 NZ_CP033102:3851552-3851770 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T113156 NZ_CP033102:3851552-3851770 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT113156 WP_006809850.1 NZ_CP033102:3851149-3851523 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT113156 NZ_CP033102:3851149-3851523 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References