Detailed information of TA system TA113154

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3051434..3052065
• Replicon: chromosome
• Accession: NZ_CP033102
• Organism: Enterobacter hormaechei strain L51

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: D8768_RS14775
• Protein ID: WP_157507902.1
• Coordinates: 3051790..3052065 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: D8768_RS14770
• Protein ID: WP_157507900.1
• Coordinates: 3051434..3051793 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8768_RS14755	3047192..3048028	-	837	WP_148735444.1	GPO family capsid scaffolding protein	-
D8768_RS14760	3048188..3049918	+	1731	WP_157507896.1	terminase family protein	-
D8768_RS14765	3049918..3050976	+	1059	WP_157507898.1	phage portal protein	-
D8768_RS14770	3051434..3051793	-	360	WP_157507900.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
D8768_RS14775	3051790..3052065	-	276	WP_157507902.1	type II toxin-antitoxin system HicA family toxin	Toxin
D8768_RS14780	3052135..3052374	-	240	WP_157507904.1	hypothetical protein	-
D8768_RS14785	3052367..3053071	-	705	WP_157507906.1	DNA adenine methylase	-
D8768_RS14790	3053271..3055670	-	2400	WP_157508625.1	replication endonuclease	-
D8768_RS14795	3055780..3056181	+	402	WP_157507908.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3028068..3066584	38516

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-79)

Antitoxin

• Uncharacterised protein family HicB (60-112)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10129.68 Da
• Isoelectric Point: 10.7068

>T113154 WP_157507902.1 NZ_CP033102:c3052065-3051790 [Enterobacter hormaechei]
MKEKVSSLRKKQKSTLEQIFKTPVQSGIKWADIESLIRALGGEVKEGRGSRCKFILNGSIANFHRPHPSPDTDKGAVVNL
RDWLESTGVKP

Nucleotide

• Length: 276 bp

>T113154 NZ_CP033102:c3052065-3051790 [Enterobacter hormaechei]
ATGAAAGAGAAGGTTTCATCGCTACGGAAGAAGCAAAAAAGCACGCTTGAGCAGATATTTAAAACGCCCGTTCAGTCGGG
CATTAAATGGGCTGATATCGAGTCACTGATCAGGGCGCTGGGAGGGGAAGTCAAAGAGGGGCGCGGTTCCCGCTGTAAGT
TTATCCTTAACGGCAGTATCGCTAATTTTCATCGCCCCCACCCTTCGCCAGATACAGACAAAGGCGCAGTAGTTAACCTG
CGTGACTGGCTTGAGAGCACAGGAGTTAAGCCATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13261.96 Da
• Isoelectric Point: 4.9313

>AT113154 WP_157507900.1 NZ_CP033102:c3051793-3051434 [Enterobacter hormaechei]
MSKPSTPNTIDIAGQPAIINYVPELGAFRGKFLGLTGYCDFVSDSIQGLKKEGEISLREYLEDCSAAGIEPYARQEKVKT
FTLRYPESFGERLNQAAAEHETSVNTFIIETLNERMKHA

Nucleotide

• Length: 360 bp

>AT113154 NZ_CP033102:c3051793-3051434 [Enterobacter hormaechei]
ATGAGCAAACCATCAACACCCAATACCATTGATATCGCCGGACAGCCAGCCATTATCAACTACGTGCCGGAACTCGGCGC
GTTTCGCGGCAAGTTTCTGGGGCTGACCGGCTATTGTGATTTTGTCTCCGACAGTATTCAGGGGCTGAAAAAAGAAGGTG
AGATTTCACTGCGTGAATATCTTGAGGATTGCAGCGCGGCGGGAATTGAACCTTATGCGCGTCAGGAGAAGGTTAAAACA
TTCACACTCCGATACCCGGAATCATTTGGTGAGCGACTGAATCAGGCCGCAGCTGAGCATGAAACCTCAGTCAACACTTT
TATTATTGAGACGCTAAACGAGCGAATGAAACACGCCTGA