Detailed information of TA system TA113152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2429803..2430542
• Replicon: chromosome
• Accession: NZ_CP033102
• Organism: Enterobacter hormaechei strain L51

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: D8768_RS11625
• Protein ID: WP_063139083.1
• Coordinates: 2430057..2430542 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A837FCR9
• Locus tag: D8768_RS11620
• Protein ID: WP_003857131.1
• Coordinates: 2429803..2430069 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8768_RS11595	2424951..2425475	+	525	WP_087878309.1	fimbrial protein	-
D8768_RS11600	2425499..2426635	+	1137	WP_032624240.1	type 1 fimbrial protein	-
D8768_RS11605	2426756..2427313	+	558	WP_157507572.1	hypothetical protein	-
D8768_RS11610	2427292..2428680	-	1389	WP_157507574.1	MFS transporter	-
D8768_RS11615	2428810..2429739	+	930	WP_157507576.1	LysR family transcriptional regulator	-
D8768_RS11620	2429803..2430069	+	267	WP_003857131.1	DUF1778 domain-containing protein	Antitoxin
D8768_RS11625	2430057..2430542	+	486	WP_063139083.1	GNAT family N-acetyltransferase	Toxin
D8768_RS11630	2430648..2430830	-	183	Protein_2268	DUF4225 domain-containing protein	-
D8768_RS11635	2431486..2431788	+	303	WP_157507578.1	hypothetical protein	-
D8768_RS11640	2431908..2433332	-	1425	WP_138159198.1	restriction endonuclease	-
D8768_RS11645	2433502..2433746	+	245	Protein_2271	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (58-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17544.22 Da
• Isoelectric Point: 9.6275

>T113152 WP_063139083.1 NZ_CP033102:2430057-2430542 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T113152 NZ_CP033102:2430057-2430542 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTACTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10090.50 Da
• Isoelectric Point: 4.3837

>AT113152 WP_003857131.1 NZ_CP033102:2429803-2430069 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT113152 NZ_CP033102:2429803-2430069 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTCGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A837FCR9