Detailed information of TA system TA113139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1950654..1951116
• Replicon: chromosome
• Accession: NZ_CP033098
• Organism: Staphylococcus warneri strain SWO

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A2V3ZEQ2
• Locus tag: EAH52_RS09535
• Protein ID: WP_002465948.1
• Coordinates: 1950931..1951116 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A364UQZ8
• Locus tag: EAH52_RS09530
• Protein ID: WP_015365250.1
• Coordinates: 1950654..1950911 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAH52_RS09490	1945862..1946185	+	324	WP_015365247.1	thioredoxin family protein	-
EAH52_RS09495	1946297..1946836	-	540	WP_002465937.1	nitroreductase	-
EAH52_RS09500	1946914..1947630	-	717	WP_002465941.1	type I 3-dehydroquinate dehydratase	-
EAH52_RS09505	1947806..1948228	+	423	WP_002450862.1	organic hydroperoxide resistance protein	-
EAH52_RS09510	1948506..1949000	+	495	WP_002465942.1	GNAT family N-acetyltransferase	-
EAH52_RS09515	1949133..1949723	-	591	WP_002465945.1	histidine phosphatase family protein	-
EAH52_RS09520	1949932..1950165	+	234	WP_002450865.1	hypothetical protein	-
EAH52_RS09525	1950157..1950360	-	204	WP_002465950.1	sterile alpha motif-like domain-containing protein	-
EAH52_RS09530	1950654..1950911	+	258	WP_015365250.1	hypothetical protein	Antitoxin
EAH52_RS09535	1950931..1951116	+	186	WP_002465948.1	hypothetical protein	Toxin
EAH52_RS09540	1951217..1951798	+	582	WP_015365251.1	hypothetical protein	-
EAH52_RS09545	1951858..1952091	-	234	WP_002450870.1	hypothetical protein	-
EAH52_RS09550	1952356..1953108	+	753	WP_002465946.1	poly-gamma-glutamate hydrolase family protein	-
EAH52_RS09555	1953199..1953483	+	285	WP_002465939.1	hypothetical protein	-
EAH52_RS09560	1953561..1953776	+	216	WP_002465949.1	hypothetical protein	-
EAH52_RS09565	1954241..1954480	+	240	WP_002465943.1	hypothetical protein	-
EAH52_RS09570	1954709..1954942	+	234	WP_015365252.1	hypothetical protein	-
EAH52_RS09575	1955117..1955317	-	201	WP_002450876.1	cold-shock protein	-
EAH52_RS09580	1955638..1956003	-	366	WP_002466279.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-125)

Antitoxin

• Ribbon-helix-helix protein, CopG (11-49)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6977.68 Da
• Isoelectric Point: 10.1605

>T113139 WP_002465948.1 NZ_CP033098:1950931-1951116 [Staphylococcus warneri]
MSLHFTILFWLSLIFIVAGAIILAIMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLLFGL

Nucleotide

• Length: 186 bp

>T113139 NZ_CP033098:1950931-1951116 [Staphylococcus warneri]
ATGAGCTTGCATTTTACAATTCTTTTTTGGCTTTCACTTATATTTATCGTAGCTGGTGCGATTATTCTAGCTATCATGCT
TAAAACTAAAAAAGAATCTAAGAAAGAATCTTATCTTGGTTTCACCATTGTATTCTTCATTTTTGGATTAGCTATGTTGA
TATATACATTGTTATTCGGACTCTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9908.17 Da
• Isoelectric Point: 4.5910

>AT113139 WP_015365250.1 NZ_CP033098:1950654-1950911 [Staphylococcus warneri]
MKLYIIHAINIILTILFIIFNVIITYNANLDDTLWLVPGLIVCGLIMMISFAIAITKKDLLSEVLFFINIILTLYYIYPI
FYDFL

Nucleotide

• Length: 258 bp

>AT113139 NZ_CP033098:1950654-1950911 [Staphylococcus warneri]
ATGAAACTATACATTATACATGCAATCAATATTATTTTAACGATATTATTTATTATTTTTAATGTAATTATTACTTATAA
TGCAAACCTAGACGATACCTTATGGTTAGTGCCTGGATTAATTGTATGCGGTTTGATTATGATGATTAGTTTTGCTATTG
CTATAACTAAAAAGGACTTGTTAAGTGAAGTTCTTTTCTTTATTAATATTATTCTTACACTGTACTACATTTATCCAATT
TTTTATGATTTTCTTTAA

Structures

Toxin

• AlphaFold DB: A0A2V3ZEQ2

Antitoxin

• AlphaFold DB: A0A364UQZ8