Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 992114..992920 Replicon chromosome
Accession NZ_CP033098
Organism Staphylococcus warneri strain SWO

Toxin (Protein)


Gene name tsbT Uniprot ID A0A364UNB4
Locus tag EAH52_RS04965 Protein ID WP_002466824.1
Coordinates 992741..992920 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A364UN40
Locus tag EAH52_RS04960 Protein ID WP_015364870.1
Coordinates 992114..992713 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAH52_RS04940 987915..989375 + 1461 WP_002466813.1 ABC transporter substrate-binding protein/permease -
EAH52_RS04945 989368..990090 + 723 WP_002466809.1 amino acid ABC transporter ATP-binding protein -
EAH52_RS04950 990333..991463 + 1131 WP_002466804.1 tRNA epoxyqueuosine(34) reductase QueG -
EAH52_RS04955 991464..991934 + 471 WP_002466802.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EAH52_RS04960 992114..992713 + 600 WP_015364870.1 glucosamine-6-phosphate isomerase Antitoxin
EAH52_RS04965 992741..992920 + 180 WP_002466824.1 hypothetical protein Toxin
EAH52_RS04970 993063..993455 + 393 WP_015364871.1 hypothetical protein -
EAH52_RS04975 993610..994995 + 1386 WP_002466811.1 class II fumarate hydratase -
EAH52_RS04980 995056..995886 - 831 WP_122135072.1 RluA family pseudouridine synthase -
EAH52_RS04985 996064..997176 + 1113 WP_002466816.1 GAF domain-containing sensor histidine kinase -
EAH52_RS04990 997197..997820 + 624 WP_002466822.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6901.22 Da        Isoelectric Point: 3.8441

>T113135 WP_002466824.1 NZ_CP033098:992741-992920 [Staphylococcus warneri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Download         Length: 180 bp

>T113135 NZ_CP033098:992741-992920 [Staphylococcus warneri]
ATGACTCAAAATAAAGATTCTAAAACGAATTACCACGAAGAAGAAAATGCAATGGTAACCGATTTAGATGATTTAAAAGA
CTTAGGAAAAGAAATGGAACAAATTTCTGAAGAAAATGATGAAGAAAAATTAAATCAATCTCATGATTCAGATGTTCGTT
CTGATTTAGATCAAGATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22602.48 Da        Isoelectric Point: 4.8492

>AT113135 WP_015364870.1 NZ_CP033098:992114-992713 [Staphylococcus warneri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT113135 NZ_CP033098:992114-992713 [Staphylococcus warneri]
ATGGCAATGAACTTTAAAGTATTTGAAGATAAACAAAGAGTAGCTGAATATACAGCAGACATTTTGAGAAAACAATTTAA
TAACAACCCAATGACAATCGCAGGTGTTCATTTAACAAAAGATCATGCACCTGTATTAGATGAATTAAAAAAGAATGTTG
ATTTACATGCAGTTGATTTCAGTCAAATTAATATTTTAGATTATGATGAAAATCAATCATATTATGAAGCGTTAGGTGTA
CCACAAAGCCAAATTTATTCATTATCATACAACCAAGATGCTAATGACTTTATTTCAGATAAAATTAAAACAAAGGAAAA
TAAAGGTAAATTAGTCTTACAAGTTGTTTCAATTGATGAAAATGGTAATTTAGATGTAAGTGTAAGACAAGGGTTATTAG
AAGCACGCGAAATCTTCTTAGTTGTTACTGGTAGTAATAAACGTGAAGTAGTCGAAAAATTATATAACGAAAATGGAAAA
TCTAATTTTGAACCTGCAGACTTAAAAGCGCACCGTATGGTTAACGTTATTTTAGATAAAGAAGCAGCAGCTGGATTACC
TGAAGACGTGAAAGAATACTTCACAGCTCGCTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A364UN40

References