Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 837664..838193 Replicon chromosome
Accession NZ_CP033098
Organism Staphylococcus warneri strain SWO

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag EAH52_RS04045 Protein ID WP_002451625.1
Coordinates 837831..838193 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag EAH52_RS04040 Protein ID WP_002451626.1
Coordinates 837664..837834 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAH52_RS04015 833489..833962 + 474 WP_002466763.1 PH domain-containing protein -
EAH52_RS04020 833955..835481 + 1527 WP_002466774.1 PH domain-containing protein -
EAH52_RS04025 835468..835971 + 504 WP_015364833.1 PH domain-containing protein -
EAH52_RS04030 835998..836372 + 375 WP_002466788.1 holo-ACP synthase -
EAH52_RS04035 836424..837572 + 1149 WP_015364834.1 alanine racemase -
EAH52_RS04040 837664..837834 + 171 WP_002451626.1 hypothetical protein Antitoxin
EAH52_RS04045 837831..838193 + 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EAH52_RS04055 838516..839517 + 1002 WP_002466762.1 PP2C family protein-serine/threonine phosphatase -
EAH52_RS04060 839611..839937 + 327 WP_002466754.1 anti-sigma factor antagonist -
EAH52_RS04065 839939..840418 + 480 WP_002466768.1 anti-sigma B factor RsbW -
EAH52_RS04070 840393..841163 + 771 WP_002451621.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T113134 WP_002451625.1 NZ_CP033098:837831-838193 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

>T113134 NZ_CP033098:837831-838193 [Staphylococcus warneri]
ATGATTAGAAGAGGAGATGTTTATCTAGCAGATTTATCACCTGTTCAAGGGTCAGAACAAGGGGGAGTAAGACCCGTCGT
CATTATCCAAAATGACACAGGTAATAAATATAGTCCTACTGTTATTGTTGCCGCAATCACTGGAAGGATTAATAAAGCTA
AGATACCTACACATGTTGAAATTGAAAAGAAAAAGTACAAACTTGATAAGGACTCAGTTATTTTATTAGAACAAATTCGT
ACTTTAGATAAAAATCGTTTAAAAGAAAAACTCACATATTTGTCTGATAACAAAATGAAAGAAGTAGATTACGCCCTAGA
CATTAGTCTAGGTTTACATAATTTCAATCATTCTAAGACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT113134 WP_002451626.1 NZ_CP033098:837664-837834 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT113134 NZ_CP033098:837664-837834 [Staphylococcus warneri]
ATGTTATCTTTTAATCAAAATAGAAGTTATAGTTTAGAGCAATCTTTAAAAGAAGGTTATGCACAAATGGCTGATTTAAA
TCTCTCCCTAGCAACCGAAGCTTTTCCTATTGAATGTGAAGCGTGCGATTGCAATGAAACATATTTAACTTCTAACGCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References