Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 826541..827051 Replicon chromosome
Accession NZ_CP033098
Organism Staphylococcus warneri strain SWO

Toxin (Protein)


Gene name TsdT Uniprot ID A0A364UNH7
Locus tag EAH52_RS03985 Protein ID WP_002466743.1
Coordinates 826845..827051 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag EAH52_RS03980 Protein ID WP_002466760.1
Coordinates 826541..826834 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAH52_RS03955 821667..822458 + 792 WP_002466779.1 hydroxyethylthiazole kinase -
EAH52_RS03960 822459..823100 + 642 WP_015364827.1 thiamine phosphate synthase -
EAH52_RS03965 823189..824058 + 870 WP_002466746.1 membrane protein insertase YidC -
EAH52_RS03970 824096..824740 - 645 WP_002466781.1 HD domain-containing protein -
EAH52_RS03975 824868..826352 - 1485 WP_002466786.1 cardiolipin synthase -
EAH52_RS03980 826541..826834 + 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
EAH52_RS03985 826845..827051 + 207 WP_002466743.1 heavy-metal-associated domain-containing protein Toxin
EAH52_RS03990 827190..827327 + 138 WP_002466770.1 hypothetical protein -
EAH52_RS03995 827467..828657 - 1191 WP_002466775.1 rod shape-determining protein RodA -
EAH52_RS04000 829015..830085 + 1071 WP_002466764.1 D-alanine--D-alanine ligase -
EAH52_RS04005 830101..831462 + 1362 WP_002466757.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7670.62 Da        Isoelectric Point: 3.8601

>T113133 WP_002466743.1 NZ_CP033098:826845-827051 [Staphylococcus warneri]
VQQKIVYTAGIETQEQSEAIKNLLTEMIGVYQVDIDINSGNITIEFETPANLNSIEKEIYDAGYKVLY

Download         Length: 207 bp

>T113133 NZ_CP033098:826845-827051 [Staphylococcus warneri]
GTGCAACAAAAAATTGTATATACTGCTGGAATAGAAACACAAGAACAATCTGAAGCTATAAAAAATCTTTTAACTGAAAT
GATAGGTGTATATCAAGTTGATATTGATATCAATTCTGGAAACATAACAATTGAATTTGAGACACCTGCGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGCTGGATATAAAGTGCTCTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT113133 WP_002466760.1 NZ_CP033098:826541-826834 [Staphylococcus warneri]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT113133 NZ_CP033098:826541-826834 [Staphylococcus warneri]
GTGACAGAACAAGATCATGCACATCACTCTGAACAAATTAAAGTCAATTTAAAATCGAGATTAAACCGAATTGAAGGTCA
AGTTAGAGCTATTAATCGAATGATAGAAGAGGATGTTTATTGCGATGATGTGTTAACTCAAATTAGAGCTACACGTTCTG
CATTAAATAGTGTAGCTACTAAATTATTAGAACAACATATGAAAAGTTGTATAGCAGATAAAGTAAATCAAGGTCATCAA
GAAGAAGCAATGGAGGAACTACTCGTTACGTTTCAAAAATTAATGAAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNH7

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References