113105

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4119821..4120635 Replicon chromosome
Accession NZ_CP033092
Organism Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag EAS44_RS21160 Protein ID WP_001054376.1
Coordinates 4119821..4120078 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag EAS44_RS21165 Protein ID WP_001338189.1
Coordinates 4120090..4120635 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAS44_RS21140 4115109..4116215 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
EAS44_RS21145 4116280..4117260 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EAS44_RS21150 4117843..4119083 - 1241 Protein_3927 helicase YjhR -
EAS44_RS21155 4119199..4119444 + 246 Protein_3928 GNAT family N-acetyltransferase -
EAS44_RS21160 4119821..4120078 + 258 WP_001054376.1 hypothetical protein Toxin
EAS44_RS21165 4120090..4120635 + 546 WP_001338189.1 N-acetyltransferase Antitoxin
EAS44_RS21170 4120691..4121437 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EAS44_RS21175 4121606..4121824 + 219 Protein_3932 hypothetical protein -
EAS44_RS25420 4121862..4121978 + 117 Protein_3933 VOC family protein -
EAS44_RS21180 4122223..4123344 + 1122 WP_000010829.1 M42 family metallopeptidase -
EAS44_RS21185 4123341..4123619 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EAS44_RS21190 4123631..4124944 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4108843..4128859 20016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T113105 WP_001054376.1 NZ_CP033092:4119821-4120078 [Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T113105 NZ_CP033092:4119821-4120078 [Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT113105 WP_001338189.1 NZ_CP033092:4120090-4120635 [Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT113105 NZ_CP033092:4120090-4120635 [Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTTAGCAAAGAAGCCGATTTAGTGACCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References