Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1045595..1046154 Replicon chromosome
Accession NZ_CP033078
Organism Vibrio zhugei strain HBUAS61001

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EAE30_RS10175 Protein ID WP_123015810.1
Coordinates 1045595..1045873 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EAE30_RS10180 Protein ID WP_123015811.1
Coordinates 1045873..1046154 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAE30_RS10150 1040930..1041700 + 771 Protein_918 GNAT family N-acetyltransferase -
EAE30_RS10155 1041829..1042260 + 432 WP_123015809.1 nuclear transport factor 2 family protein -
EAE30_RS10160 1042363..1042533 + 171 Protein_920 AraC family transcriptional regulator -
EAE30_RS10165 1043178..1044289 + 1112 Protein_921 IS3 family transposase -
EAE30_RS10170 1044314..1045356 + 1043 Protein_922 IS3 family transposase -
EAE30_RS10175 1045595..1045873 - 279 WP_123015810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EAE30_RS10180 1045873..1046154 - 282 WP_123015811.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EAE30_RS10185 1046604..1046963 + 360 Protein_925 transposase family protein -
EAE30_RS10190 1047077..1047415 - 339 WP_123015812.1 cytosolic protein -
EAE30_RS10195 1047504..1047833 - 330 WP_123015813.1 hypothetical protein -
EAE30_RS10200 1048098..1049258 - 1161 WP_123015814.1 MFS transporter -
EAE30_RS10205 1049602..1050081 - 480 WP_123015815.1 hypothetical protein -
EAE30_RS10210 1050071..1050415 - 345 WP_123015816.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1033602..1050415 16813
- inside IScluster/Tn - - 1043178..1046963 3785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10945.54 Da        Isoelectric Point: 4.3430

>T113069 WP_123015810.1 NZ_CP033078:c1045873-1045595 [Vibrio zhugei]
MIYWEEESLNDREKIFEFLYDFNPDVAERTDDIIEAKVENLNEQPLMGVQRDGIRGRLLIIPEVSMIVSYFVDGSNIRIM
RVLHQKQKFPIE

Download         Length: 279 bp

>T113069 NZ_CP033078:c1045873-1045595 [Vibrio zhugei]
ATGATTTACTGGGAAGAAGAGTCTTTAAACGACCGAGAAAAAATCTTTGAGTTTCTGTACGATTTTAACCCTGATGTAGC
TGAAAGAACCGACGACATTATTGAAGCCAAAGTTGAAAACCTAAATGAACAACCGTTAATGGGAGTTCAACGTGATGGCA
TTCGAGGTCGATTACTCATTATTCCTGAAGTATCAATGATCGTTTCGTATTTTGTCGATGGTTCTAATATTCGAATTATG
CGTGTTCTTCATCAAAAGCAAAAATTCCCAATTGAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10767.03 Da        Isoelectric Point: 9.2520

>AT113069 WP_123015811.1 NZ_CP033078:c1046154-1045873 [Vibrio zhugei]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRDLTEQLAEQQRKALSHDAWLTEQVNLAFDKFDSGRAVFVDHESAKNR
MASRKAKIRNRGQ

Download         Length: 282 bp

>AT113069 NZ_CP033078:c1046154-1045873 [Vibrio zhugei]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGTTTAGCCCAACAAATGGCTGAAAGCCAAGGTCGAAC
GCTTAGTGATGCTTGCCGTGACCTCACCGAACAACTCGCTGAACAACAACGTAAAGCATTATCCCATGATGCTTGGCTAA
CTGAACAAGTTAATCTCGCATTTGATAAATTTGACTCTGGGCGAGCTGTATTCGTTGACCATGAATCAGCCAAAAATCGT
ATGGCTTCTCGCAAAGCAAAAATCCGTAACCGGGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References