Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 4704995..4705511 Replicon chromosome
Accession NZ_CP033076
Organism Buttiauxella sp. 3AFRM03

Toxin (Protein)


Gene name relB Uniprot ID A0A3G2IJE2
Locus tag D8682_RS23410 Protein ID WP_064545091.1
Coordinates 4705242..4705511 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A3G2ILV1
Locus tag D8682_RS23405 Protein ID WP_064545089.1
Coordinates 4704995..4705258 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8682_RS23390 4700620..4701732 + 1113 WP_121815232.1 iron-sulfur cluster carrier protein ApbC -
D8682_RS23395 4702528..4704216 + 1689 WP_121815765.1 sensor histidine kinase -
D8682_RS23400 4704210..4704938 + 729 WP_064545087.1 two-component system response regulator BtsR -
D8682_RS23405 4704995..4705258 + 264 WP_064545089.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
D8682_RS23410 4705242..4705511 + 270 WP_064545091.1 Txe/YoeB family addiction module toxin Toxin
D8682_RS23415 4705580..4706050 + 471 WP_064545093.1 DUF1456 family protein -
D8682_RS23420 4706096..4707064 - 969 WP_121815233.1 XdhC family protein -
D8682_RS23425 4707051..4707641 - 591 WP_121815234.1 nucleotidyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10747.17 Da        Isoelectric Point: 8.0291

>T113066 WP_064545091.1 NZ_CP033076:4705242-4705511 [Buttiauxella sp. 3AFRM03]
MKTTNRLLAWTDHAWDDYLWWQTQDRKTLKRINKLIEDAQRNPFDGLGKPEPLRENLSGLWSRRINEADRLVYSVSDDLL
TIFQCRLHY

Download         Length: 270 bp

>T113066 NZ_CP033076:4705242-4705511 [Buttiauxella sp. 3AFRM03]
ATGAAGACAACGAATAGATTACTCGCATGGACCGATCACGCCTGGGATGATTATCTATGGTGGCAAACGCAAGATAGAAA
GACGTTAAAGCGCATTAATAAACTGATTGAAGATGCGCAAAGAAATCCTTTTGATGGTTTAGGAAAACCTGAACCGTTAC
GTGAAAACCTCAGTGGGTTGTGGTCCCGGCGGATAAACGAGGCAGATCGTCTGGTTTATAGTGTTAGCGACGATCTGCTC
ACCATTTTCCAGTGTCGCCTGCATTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9803.01 Da        Isoelectric Point: 4.2336

>AT113066 WP_064545089.1 NZ_CP033076:4704995-4705258 [Buttiauxella sp. 3AFRM03]
MQVITFSEARNRLKTVLDDVVDNADITVITRRDAEDAVVMSLDYYNSLMETVHLLSSPANATRLMESMAQAQAGKISRRE
IIDEDNE

Download         Length: 264 bp

>AT113066 NZ_CP033076:4704995-4705258 [Buttiauxella sp. 3AFRM03]
ATGCAGGTTATTACATTTTCTGAGGCGCGTAATCGGCTCAAAACCGTTCTTGATGACGTTGTGGACAATGCCGATATTAC
AGTTATCACCCGCCGTGATGCTGAAGATGCGGTAGTGATGTCGTTGGATTACTACAATTCCTTGATGGAAACCGTTCATT
TGCTCAGCTCTCCGGCAAATGCGACACGCCTGATGGAATCAATGGCGCAGGCACAGGCAGGTAAAATCTCACGGAGAGAG
ATTATTGATGAAGACAACGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2IJE2

Antitoxin

Source ID Structure
AlphaFold DB A0A3G2ILV1

References