Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3312522..3313109 Replicon chromosome
Accession NZ_CP033076
Organism Buttiauxella sp. 3AFRM03

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag D8682_RS16830 Protein ID WP_121815722.1
Coordinates 3312522..3312842 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag D8682_RS16835 Protein ID WP_083963253.1
Coordinates 3312855..3313109 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8682_RS16815 3310025..3310930 + 906 WP_064542691.1 formate dehydrogenase subunit beta -
D8682_RS16820 3310927..3311562 + 636 WP_064542693.1 formate dehydrogenase cytochrome b556 subunit -
D8682_RS16825 3311559..3312488 + 930 WP_064542696.1 formate dehydrogenase accessory protein FdhE -
D8682_RS16830 3312522..3312842 - 321 WP_121815722.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
D8682_RS16835 3312855..3313109 - 255 WP_083963253.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D8682_RS16845 3313392..3314306 + 915 WP_121814741.1 alpha/beta hydrolase -
D8682_RS16850 3314353..3314574 - 222 WP_121814742.1 YgdI/YgdR family lipoprotein -
D8682_RS16860 3315295..3315573 + 279 WP_121814743.1 hypothetical protein -
D8682_RS16865 3315643..3316173 - 531 WP_121814744.1 hypothetical protein -
D8682_RS16870 3316304..3316495 + 192 WP_121814745.1 hypothetical protein -
D8682_RS16875 3316558..3317790 + 1233 WP_121814746.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-105)

Antitoxin

SpoVT-AbrB domain

(6-47)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11982.79 Da        Isoelectric Point: 7.4253

>T113063 WP_121815722.1 NZ_CP033076:c3312842-3312522 [Buttiauxella sp. 3AFRM03]
MPDRGDLVWLDFDPAAGHEQAKTRPALVLSPVEFSRKAGMAIVAPITSRVRGNAFEVHLTETHTRGVVICHHVKSIDFRA
RQMRFIEKAPEEVTEEALSRVKVFFE

Download         Length: 321 bp

>T113063 NZ_CP033076:c3312842-3312522 [Buttiauxella sp. 3AFRM03]
ATGCCTGATAGAGGCGATTTAGTGTGGCTCGATTTTGATCCTGCCGCTGGTCACGAACAAGCCAAAACTCGGCCTGCGCT
AGTATTGTCACCAGTCGAATTTAGCCGCAAGGCTGGCATGGCGATTGTGGCACCAATAACATCTCGTGTTCGTGGCAATG
CGTTTGAAGTACATCTGACAGAAACTCACACCCGGGGAGTTGTCATTTGCCATCATGTTAAATCAATCGATTTCCGGGCC
AGACAGATGCGTTTCATTGAAAAAGCACCTGAAGAAGTCACAGAAGAGGCGCTGTCCAGAGTGAAGGTATTTTTCGAATA
A

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9119.46 Da        Isoelectric Point: 4.3449

>AT113063 WP_083963253.1 NZ_CP033076:c3313109-3312855 [Buttiauxella sp. 3AFRM03]
VKTLIRKWGNSAGAIIPAAVLEKAGMRIGDKVDIEAVEGGIMLRVAKPIYTLSELLAQSPEGSFELDDEDREWLNSPPVG
KEID

Download         Length: 255 bp

>AT113063 NZ_CP033076:c3313109-3312855 [Buttiauxella sp. 3AFRM03]
GTGAAAACGCTGATTCGTAAATGGGGTAATTCCGCAGGGGCCATTATTCCTGCAGCTGTTCTGGAGAAAGCTGGGATGAG
AATAGGTGACAAAGTGGATATTGAAGCCGTTGAGGGTGGAATTATGTTGCGAGTCGCAAAGCCGATATACACGCTAAGTG
AGTTACTGGCCCAATCACCCGAAGGAAGTTTCGAGCTTGATGATGAAGACCGTGAGTGGCTGAATTCTCCGCCTGTTGGC
AAGGAGATCGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References