Detailed information of TA system TA113044

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2895104..2895635
• Replicon: chromosome
• Accession: NZ_CP033073
• Organism: Streptomyces sp. Z022

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D9753_RS12665
• Protein ID: WP_121787122.1
• Coordinates: 2895366..2895635 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D9753_RS12660
• Protein ID: WP_121787121.1
• Coordinates: 2895104..2895373 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D9753_RS12640	2890511..2891263	-	753	WP_121787117.1	GntR family transcriptional regulator	-
D9753_RS12645	2891751..2892929	+	1179	WP_205614387.1	proteinase inhibitor I4 serpin	-
D9753_RS12650	2893022..2894020	-	999	WP_121787119.1	2,3-diaminopropionate biosynthesis protein SbnB	-
D9753_RS12655	2894210..2894518	-	309	WP_121787120.1	AzlD domain-containing protein	-
D9753_RS36525	2894531..2894863	-	333	WP_163010690.1	hypothetical protein	-
D9753_RS12660	2895104..2895373	+	270	WP_121787121.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D9753_RS12665	2895366..2895635	+	270	WP_121787122.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D9753_RS12670	2895714..2895989	+	276	WP_014048106.1	hypothetical protein	-
D9753_RS12675	2895986..2896393	+	408	WP_121787123.1	PIN domain-containing protein	-
D9753_RS12680	2896407..2897599	-	1193	Protein_2422	type I restriction endonuclease subunit R	-
D9753_RS12685	2897611..2898555	+	945	Protein_2423	hypothetical protein	-
D9753_RS12690	2898552..2898899	+	348	WP_121787124.1	hypothetical protein	-
D9753_RS12695	2898896..2899282	+	387	WP_121787125.1	hypothetical protein	-
D9753_RS12700	2899516..2899710	+	195	Protein_2426	hypothetical protein	-
D9753_RS12705	2899763..2900275	+	513	WP_205614136.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10281.86 Da
• Isoelectric Point: 10.3620

>T113044 WP_121787122.1 NZ_CP033073:2895366-2895635 [Streptomyces sp. Z022]
VSEYRTVFRPEAQAELRKIRRDMALRILAKLTELESDPLGFNTTALVSQPERRRLRGGDYRVVYTIDNGELVVWVVHVST
GFSAKYKKI

Nucleotide

• Length: 270 bp

>T113044 NZ_CP033073:2895366-2895635 [Streptomyces sp. Z022]
GTGAGTGAGTACCGAACCGTCTTCCGACCGGAGGCGCAGGCCGAGCTCCGGAAGATCCGTCGCGACATGGCCTTGCGCAT
CCTGGCCAAACTGACCGAGCTGGAGAGCGACCCCCTCGGCTTCAACACCACCGCGCTCGTGTCACAGCCAGAACGCCGTC
GACTGCGGGGCGGCGACTACCGGGTCGTCTACACGATCGACAACGGAGAGCTCGTGGTGTGGGTCGTCCACGTCAGCACG
GGATTCTCGGCAAAGTACAAGAAGATCTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10286.78 Da
• Isoelectric Point: 4.7473

>AT113044 WP_121787121.1 NZ_CP033073:2895104-2895373 [Streptomyces sp. Z022]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPVPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT113044 NZ_CP033073:2895104-2895373 [Streptomyces sp. Z022]
ATGACGCAGCCCCTACCCATAGAGTCCATCCGCGACGTACGCGCGCACCTAGCCGAGGTCGTGGAGCGCGCCGATCGAGA
CGACGTGCCCACCGTGATCACCCGACGGGGCAAGCAGGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCTGTACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA