Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2895104..2895635 Replicon chromosome
Accession NZ_CP033073
Organism Streptomyces sp. Z022

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D9753_RS12665 Protein ID WP_121787122.1
Coordinates 2895366..2895635 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D9753_RS12660 Protein ID WP_121787121.1
Coordinates 2895104..2895373 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9753_RS12640 2890511..2891263 - 753 WP_121787117.1 GntR family transcriptional regulator -
D9753_RS12645 2891751..2892929 + 1179 WP_205614387.1 proteinase inhibitor I4 serpin -
D9753_RS12650 2893022..2894020 - 999 WP_121787119.1 2,3-diaminopropionate biosynthesis protein SbnB -
D9753_RS12655 2894210..2894518 - 309 WP_121787120.1 AzlD domain-containing protein -
D9753_RS36525 2894531..2894863 - 333 WP_163010690.1 hypothetical protein -
D9753_RS12660 2895104..2895373 + 270 WP_121787121.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D9753_RS12665 2895366..2895635 + 270 WP_121787122.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D9753_RS12670 2895714..2895989 + 276 WP_014048106.1 hypothetical protein -
D9753_RS12675 2895986..2896393 + 408 WP_121787123.1 PIN domain-containing protein -
D9753_RS12680 2896407..2897599 - 1193 Protein_2422 type I restriction endonuclease subunit R -
D9753_RS12685 2897611..2898555 + 945 Protein_2423 hypothetical protein -
D9753_RS12690 2898552..2898899 + 348 WP_121787124.1 hypothetical protein -
D9753_RS12695 2898896..2899282 + 387 WP_121787125.1 hypothetical protein -
D9753_RS12700 2899516..2899710 + 195 Protein_2426 hypothetical protein -
D9753_RS12705 2899763..2900275 + 513 WP_205614136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10281.86 Da        Isoelectric Point: 10.3620

>T113044 WP_121787122.1 NZ_CP033073:2895366-2895635 [Streptomyces sp. Z022]
VSEYRTVFRPEAQAELRKIRRDMALRILAKLTELESDPLGFNTTALVSQPERRRLRGGDYRVVYTIDNGELVVWVVHVST
GFSAKYKKI

Download         Length: 270 bp

>T113044 NZ_CP033073:2895366-2895635 [Streptomyces sp. Z022]
GTGAGTGAGTACCGAACCGTCTTCCGACCGGAGGCGCAGGCCGAGCTCCGGAAGATCCGTCGCGACATGGCCTTGCGCAT
CCTGGCCAAACTGACCGAGCTGGAGAGCGACCCCCTCGGCTTCAACACCACCGCGCTCGTGTCACAGCCAGAACGCCGTC
GACTGCGGGGCGGCGACTACCGGGTCGTCTACACGATCGACAACGGAGAGCTCGTGGTGTGGGTCGTCCACGTCAGCACG
GGATTCTCGGCAAAGTACAAGAAGATCTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10286.78 Da        Isoelectric Point: 4.7473

>AT113044 WP_121787121.1 NZ_CP033073:2895104-2895373 [Streptomyces sp. Z022]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPVPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT113044 NZ_CP033073:2895104-2895373 [Streptomyces sp. Z022]
ATGACGCAGCCCCTACCCATAGAGTCCATCCGCGACGTACGCGCGCACCTAGCCGAGGTCGTGGAGCGCGCCGATCGAGA
CGACGTGCCCACCGTGATCACCCGACGGGGCAAGCAGGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCTGTACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References