Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 509854..510490 Replicon chromosome
Accession NZ_CP033064
Organism Bacillus sp. WR11

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag D9C22_RS02610 Protein ID WP_003156187.1
Coordinates 510140..510490 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag D9C22_RS02605 Protein ID WP_003225183.1
Coordinates 509854..510135 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9C22_RS02585 506214..506813 - 600 WP_041850724.1 rhomboid family intramembrane serine protease -
D9C22_RS02590 506908..507273 + 366 WP_015252768.1 holo-ACP synthase -
D9C22_RS02595 507439..508455 + 1017 WP_072557167.1 outer membrane lipoprotein carrier protein LolA -
D9C22_RS02600 508569..509738 + 1170 WP_015252766.1 alanine racemase -
D9C22_RS02605 509854..510135 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
D9C22_RS02610 510140..510490 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
D9C22_RS02615 510605..511429 + 825 WP_009966610.1 RsbT co-antagonist protein RsbRA -
D9C22_RS02620 511434..511799 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
D9C22_RS02625 511803..512204 + 402 WP_003246640.1 serine/threonine-protein kinase RsbT -
D9C22_RS02630 512216..513223 + 1008 WP_003234295.1 phosphoserine phosphatase RsbU -
D9C22_RS02635 513285..513614 + 330 WP_003234298.1 anti-sigma factor antagonist RsbV -
D9C22_RS02640 513611..514093 + 483 WP_003234299.1 anti-sigma B factor RsbW -
D9C22_RS02645 514059..514847 + 789 WP_003246715.1 RNA polymerase sigma factor SigB -
D9C22_RS02650 514847..515446 + 600 WP_003246608.1 phosphoserine phosphatase RsbX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T113026 WP_003156187.1 NZ_CP033064:510140-510490 [Bacillus sp. WR11]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T113026 NZ_CP033064:510140-510490 [Bacillus sp. WR11]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT113026 WP_003225183.1 NZ_CP033064:509854-510135 [Bacillus sp. WR11]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT113026 NZ_CP033064:509854-510135 [Bacillus sp. WR11]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References