Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3666042..3666859 Replicon chromosome
Accession NZ_CP033056
Organism Morganella morganii strain L241

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A2C5TM43
Locus tag D8758_RS17400 Protein ID WP_004236532.1
Coordinates 3666042..3666524 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag D8758_RS17405 Protein ID WP_004236533.1
Coordinates 3666551..3666859 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8758_RS17370 3661406..3662029 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
D8758_RS17375 3662048..3663043 - 996 WP_004236526.1 serine/threonine protein kinase -
D8758_RS17380 3663043..3663312 - 270 WP_004240741.1 YihD family protein -
D8758_RS17385 3663515..3664630 + 1116 WP_004236528.1 molybdenum cofactor guanylyltransferase MobA -
D8758_RS17390 3664840..3665142 + 303 WP_004236529.1 ABC transporter substrate-binding protein -
D8758_RS17395 3665270..3665791 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
D8758_RS18760 3665788..3665928 + 141 WP_164545838.1 hypothetical protein -
D8758_RS17400 3666042..3666524 - 483 WP_004236532.1 GNAT family N-acetyltransferase Toxin
D8758_RS17405 3666551..3666859 - 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
D8758_RS17410 3666991..3668343 - 1353 WP_004236534.1 glutathione-disulfide reductase -
D8758_RS17415 3668413..3669255 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
D8758_RS17420 3669445..3669834 + 390 WP_004236536.1 DUF1090 domain-containing protein -
D8758_RS17425 3670246..3671238 + 993 WP_004236539.1 inner membrane protein YhjD -
D8758_RS17430 3671346..3671552 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(36-135)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17729.48 Da        Isoelectric Point: 10.2370

>T113022 WP_004236532.1 NZ_CP033056:c3666524-3666042 [Morganella morganii]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Download         Length: 483 bp

>T113022 NZ_CP033056:c3666524-3666042 [Morganella morganii]
TTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCATTGGCTGAAAACCCGCGCATTGCA
AAATCAGCAATCCGGAGCCTCACGGACATTTGTCGTCTGCCACCATAACCGGATAATGGCCTATTATGCATTATCGACAG
GCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAAATTCCGGTTATCCTGCCGGGACGT
CTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGATGCCGCACTGCGGGTCTTGCAGGC
GGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCAGACGTTTTTATGAGCATACCGGTT
TTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAGCTGGCAACCGGCATCTATTCTGAA
TAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT113022 WP_004236533.1 NZ_CP033056:c3666859-3666551 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp

>AT113022 NZ_CP033056:c3666859-3666551 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C5TM43

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References