Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 871302..871928 Replicon chromosome
Accession NZ_CP033056
Organism Morganella morganii strain L241

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag D8758_RS04060 Protein ID WP_024474604.1
Coordinates 871302..871505 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag D8758_RS04065 Protein ID WP_004236473.1
Coordinates 871569..871928 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8758_RS04035 867858..868196 + 339 WP_004236467.1 P-II family nitrogen regulator -
D8758_RS04040 868216..869505 + 1290 WP_015422958.1 ammonium transporter AmtB -
D8758_RS04045 869566..870429 - 864 WP_004236469.1 acyl-CoA thioesterase II -
D8758_RS04060 871302..871505 - 204 WP_024474604.1 hemolysin expression modulator Hha Toxin
D8758_RS04065 871569..871928 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
D8758_RS04070 872491..875667 - 3177 WP_015422956.1 multidrug efflux RND transporter permease subunit -
D8758_RS04075 875682..876878 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T113021 WP_024474604.1 NZ_CP033056:c871505-871302 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T113021 NZ_CP033056:c871505-871302 [Morganella morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT113021 WP_004236473.1 NZ_CP033056:c871928-871569 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT113021 NZ_CP033056:c871928-871569 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTTGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References