Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4951857..4952635 Replicon chromosome
Accession NZ_CP033055
Organism Serratia sp. 3ACOL1

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag D9980_RS22420 Protein ID WP_121608477.1
Coordinates 4951857..4952345 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag D9980_RS22425 Protein ID WP_121608478.1
Coordinates 4952342..4952635 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9980_RS22395 4947128..4948444 + 1317 WP_121608473.1 glutamate/aspartate:proton symporter GltP -
D9980_RS22400 4948562..4949836 + 1275 WP_121608474.1 hypothetical protein -
D9980_RS22405 4949862..4950395 - 534 WP_121608475.1 metal-dependent hydrolase -
D9980_RS22410 4950432..4951049 - 618 WP_121609072.1 TetR/AcrR family transcriptional regulator -
D9980_RS22415 4951164..4951766 + 603 WP_121608476.1 NAD(P)H-dependent oxidoreductase -
D9980_RS22420 4951857..4952345 - 489 WP_121608477.1 GNAT family N-acetyltransferase Toxin
D9980_RS22425 4952342..4952635 - 294 WP_121608478.1 DUF1778 domain-containing protein Antitoxin
D9980_RS22430 4953065..4954168 - 1104 WP_121608479.1 hypothetical protein -
D9980_RS22440 4955163..4955846 + 684 WP_121608480.1 thermostable hemolysin -
D9980_RS22445 4955843..4957402 + 1560 WP_121608481.1 AMP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-89)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17770.85 Da        Isoelectric Point: 8.1397

>T113019 WP_121608477.1 NZ_CP033055:c4952345-4951857 [Serratia sp. 3ACOL1]
VISSPQPLRAEHVRTAFCCGVESMDNWLKQRAIKNQLTGASRTFVCCDDMKVMAYYSLASSAIMTNAAPGRFRRNMPDPI
PVVILGRLAVDQALHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSVEAREFYLRVGFEPSPLDPMMLMITLGDLIE
SL

Download         Length: 489 bp

>T113019 NZ_CP033055:c4952345-4951857 [Serratia sp. 3ACOL1]
GTGATCTCCTCCCCTCAGCCTCTCCGTGCCGAGCACGTCAGAACAGCTTTCTGCTGTGGCGTGGAAAGCATGGATAATTG
GCTGAAGCAGAGGGCGATAAAAAACCAGTTAACGGGTGCATCTCGTACCTTCGTTTGCTGTGATGACATGAAAGTGATGG
CCTATTACTCGCTGGCATCCAGCGCCATCATGACTAATGCAGCCCCTGGCCGTTTTCGCCGCAATATGCCCGACCCTATA
CCGGTGGTGATATTGGGACGGCTAGCGGTGGATCAAGCGTTACATGGGCAGGGGGTTGGGCGTGCATTAGTGCGTGATGC
AGGTTTACGGGTCATCCAGGTTGCTGAAACTATTGGCATTCGCGGAATGCTGGTGCATGCGCTATCCGTTGAGGCCAGAG
AGTTCTATCTACGAGTGGGATTTGAACCTTCCCCCCTCGATCCGATGATGTTGATGATAACGTTGGGGGATTTGATCGAG
AGTCTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.57 Da        Isoelectric Point: 10.5423

>AT113019 WP_121608478.1 NZ_CP033055:c4952635-4952342 [Serratia sp. 3ACOL1]
MSAANSVPVRRETLNLRIKTAERELIDRAAKARGKNRTDFVLDAARAAAEEALIEQRIIMVDPEAYQEFLTRLDQAPAPN
AALRKTMRSVAPWDQKK

Download         Length: 294 bp

>AT113019 NZ_CP033055:c4952635-4952342 [Serratia sp. 3ACOL1]
ATGTCGGCAGCTAATAGTGTTCCCGTAAGGCGTGAGACATTAAATCTGCGGATCAAAACCGCTGAGCGTGAGCTTATCGA
TCGTGCCGCGAAAGCCAGAGGAAAAAACCGCACCGATTTCGTGCTGGATGCCGCTCGTGCTGCCGCTGAAGAGGCACTGA
TTGAACAGCGTATTATCATGGTCGATCCCGAAGCCTACCAAGAGTTCCTGACACGTTTGGATCAAGCTCCTGCACCCAAT
GCTGCATTACGCAAGACCATGCGTTCTGTTGCACCGTGGGATCAAAAAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References