Detailed information of TA system TA113018

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 4704865..4705508
• Replicon: chromosome
• Accession: NZ_CP033055
• Organism: Serratia sp. 3ACOL1

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: U2MXY5
• Locus tag: D9980_RS21200
• Protein ID: WP_021181796.1
• Coordinates: 4704865..4705281 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: D9980_RS21205
• Protein ID: WP_121609064.1
• Coordinates: 4705278..4705508 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D9980_RS21195	4703026..4704573	-	1548	WP_121608363.1	hypothetical protein	-
D9980_RS21200	4704865..4705281	-	417	WP_021181796.1	type II toxin-antitoxin system VapC family toxin	Toxin
D9980_RS21205	4705278..4705508	-	231	WP_121609064.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D9980_RS21210	4705908..4707247	+	1340	Protein_4115	amidohydrolase family protein	-
D9980_RS21215	4707373..4707984	-	612	WP_121608364.1	hypothetical protein	-
D9980_RS21220	4708369..4708860	-	492	WP_121608365.1	hypothetical protein	-
D9980_RS21225	4708867..4709673	-	807	WP_121608366.1	winged helix family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-47)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15043.34 Da
• Isoelectric Point: 7.8858

>T113018 WP_021181796.1 NZ_CP033055:c4705281-4704865 [Serratia sp. 3ACOL1]
VNKTYMLDTNICSFIMREQPEAVIKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHAQLVDAFCARLDAVLAWDRA
AVDATTEVKAALSAAGTPIGPNDTAIAGHAIAADAILVTNNTREFARVPDLKLEDWVK

Nucleotide

• Length: 417 bp

>T113018 NZ_CP033055:c4705281-4704865 [Serratia sp. 3ACOL1]
GTGAACAAGACCTATATGCTGGACACCAACATTTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTGATTAAGCGTCT
TGAGCAGGCCGTACTGCGCAATCACCGCATCGTGGTTTCGGCCATCACCTACGCCGAGATGCGCTTTGGCGCTATCGGAA
AAAAGGCCTCCCCGCGCCACGCGCAGCTAGTCGACGCATTCTGCGCCCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCGGTGGACGCCACCACGGAAGTTAAGGCGGCGCTGTCTGCAGCCGGGACCCCCATCGGTCCCAACGACACGGCGATTGC
CGGGCATGCCATTGCGGCAGACGCCATACTGGTGACGAATAATACACGGGAATTTGCGCGGGTACCGGACCTGAAGCTGG
AGGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8844.96 Da
• Isoelectric Point: 4.4870

>AT113018 WP_121609064.1 NZ_CP033055:c4705508-4705278 [Serratia sp. 3ACOL1]
MRTVSIFKNGNNRAIRLPRDMDFEGVSELEIVREGDRIILRPIRPTWGSFTQLEKADTDFMADREDVVSDEGRFDL

Nucleotide

• Length: 231 bp

>AT113018 NZ_CP033055:c4705508-4705278 [Serratia sp. 3ACOL1]
ATGAGAACCGTATCTATTTTTAAAAATGGTAATAACCGCGCCATCCGTCTGCCGCGTGACATGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACCGTATCATTCTGCGTCCCATCCGGCCGACCTGGGGATCGTTCACACAACTCG
AAAAAGCCGACACGGACTTTATGGCGGACCGTGAGGACGTTGTCAGCGACGAAGGACGATTTGACCTGTGA

Structures

Toxin

• AlphaFold DB: U2MXY5