Detailed information of TA system TA113015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 4233652..4234403
• Replicon: chromosome
• Accession: NZ_CP033055
• Organism: Serratia sp. 3ACOL1

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: D9980_RS19130
• Protein ID: WP_121608140.1
• Coordinates: 4233921..4234403 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A3G2FKC3
• Locus tag: D9980_RS19125
• Protein ID: WP_059199145.1
• Coordinates: 4233652..4233930 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D9980_RS19105	4230922..4231671	+	750	WP_121608137.1	NAD(P)-dependent oxidoreductase	-
D9980_RS19110	4231737..4231973	-	237	WP_021181593.1	DUF4282 domain-containing protein	-
D9980_RS19115	4232166..4232393	-	228	WP_121608138.1	sulfurtransferase TusA family protein	-
D9980_RS19120	4232399..4233433	-	1035	WP_121608139.1	YeeE/YedE family protein	-
D9980_RS19125	4233652..4233930	+	279	WP_059199145.1	DUF1778 domain-containing protein	Antitoxin
D9980_RS19130	4233921..4234403	+	483	WP_121608140.1	GNAT family N-acetyltransferase	Toxin
D9980_RS19135	4234552..4235244	+	693	WP_024485069.1	HAD-IB family hydrolase	-
D9980_RS19140	4235659..4236903	-	1245	WP_121608141.1	VWA domain-containing protein	-
D9980_RS19145	4237089..4237664	-	576	WP_021807716.1	TerD family protein	-
D9980_RS19150	4237737..4238315	-	579	WP_021807715.1	tellurium resistance membrane protein TerD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (43-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-92)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17712.63 Da
• Isoelectric Point: 9.7957

>T113015 WP_121608140.1 NZ_CP033055:4233921-4234403 [Serratia sp. 3ACOL1]
MGMKAPEPLSSGHNLADFCSSEPMLNEWLRKKALKNHSAGISRVYVICAEETHRVIGYYCLATGSVQRNTAPGAYRRNAP
ESLPVIVLGRLAIDQAYSGKGLGVALLKDAIFRTKNIAQQVGVRALIVHALNEEVRNFYIKFAFSPSPEHPLMLFYPIKL

Nucleotide

• Length: 483 bp

>T113015 NZ_CP033055:4233921-4234403 [Serratia sp. 3ACOL1]
ATGGGAATGAAAGCTCCCGAGCCCTTGTCATCCGGGCATAACCTCGCTGACTTTTGCAGTTCAGAGCCGATGCTTAATGA
GTGGCTGAGAAAGAAAGCGCTTAAAAATCATAGCGCAGGAATTTCCCGCGTTTATGTTATTTGCGCAGAGGAAACCCATA
GGGTCATTGGATACTATTGCCTAGCAACTGGTAGCGTTCAGAGGAATACCGCCCCCGGAGCTTACAGACGCAATGCGCCA
GAGTCACTTCCAGTTATCGTTCTTGGCAGACTTGCTATCGATCAGGCGTACTCAGGTAAGGGTCTAGGGGTCGCATTGTT
AAAAGACGCGATATTTCGGACAAAGAATATTGCTCAACAAGTTGGCGTGAGAGCGTTAATCGTTCATGCATTGAATGAAG
AGGTGCGAAACTTCTACATCAAGTTCGCCTTCTCCCCCTCCCCTGAACACCCACTGATGCTGTTTTACCCAATAAAGCTT
TAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10641.12 Da
• Isoelectric Point: 4.4247

>AT113015 WP_059199145.1 NZ_CP033055:4233652-4233930 [Serratia sp. 3ACOL1]
MKPETREAPINIRAKASQRDLIDMAASLLSKSRTDFMLEVACREAQDILLDQRLFILDDEQYDAFLTELDAPITAERQAR
INDLMSRKSPWE

Nucleotide

• Length: 279 bp

>AT113015 NZ_CP033055:4233652-4233930 [Serratia sp. 3ACOL1]
ATGAAACCTGAAACTAGAGAAGCCCCGATCAATATTCGGGCAAAAGCGTCTCAACGCGACCTGATCGACATGGCTGCAAG
TCTCTTGTCGAAGTCGCGTACCGATTTCATGCTTGAAGTGGCTTGCCGCGAGGCGCAGGACATCCTACTGGACCAGCGTT
TGTTTATTTTAGACGACGAACAATATGATGCGTTTCTGACCGAACTGGATGCGCCTATCACCGCTGAACGCCAGGCCCGT
ATTAACGACCTGATGAGCCGCAAATCGCCATGGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G2FKC3