Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3710230..3711266 | Replicon | chromosome |
| Accession | NZ_CP033055 | ||
| Organism | Serratia sp. 3ACOL1 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | D9980_RS16670 | Protein ID | WP_121607889.1 |
| Coordinates | 3710691..3711266 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A3G2FIG6 |
| Locus tag | D9980_RS16665 | Protein ID | WP_024483048.1 |
| Coordinates | 3710230..3710691 (+) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D9980_RS16640 | 3705373..3706173 | - | 801 | WP_024483041.1 | PTS sugar transporter subunit IIC | - |
| D9980_RS16645 | 3706190..3706690 | - | 501 | WP_024483042.1 | PTS sugar transporter subunit IIB | - |
| D9980_RS16650 | 3706700..3707128 | - | 429 | WP_024483043.1 | PTS fructose transporter subunit IIA | - |
| D9980_RS16655 | 3707133..3708926 | - | 1794 | WP_202913960.1 | class I mannose-6-phosphate isomerase | - |
| D9980_RS16660 | 3709116..3710126 | + | 1011 | WP_059201845.1 | LacI family transcriptional regulator | - |
| D9980_RS16665 | 3710230..3710691 | + | 462 | WP_024483048.1 | helix-turn-helix domain-containing protein | Antitoxin |
| D9980_RS16670 | 3710691..3711266 | + | 576 | WP_121607889.1 | PIN domain-containing protein | Toxin |
| D9980_RS16675 | 3711292..3712074 | - | 783 | WP_024483049.1 | 4,5-DOPA dioxygenase extradiol | - |
| D9980_RS16680 | 3712282..3713049 | + | 768 | WP_021806868.1 | zinc transporter ZupT | - |
| D9980_RS16685 | 3713109..3713762 | - | 654 | WP_024483050.1 | 3,4-dihydroxy-2-butanone-4-phosphate synthase | - |
| D9980_RS16695 | 3714451..3714726 | + | 276 | WP_024528278.1 | accessory factor UbiK family protein | - |
| D9980_RS16700 | 3714759..3716009 | - | 1251 | WP_121607891.1 | L-methionine/branched-chain amino acid transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21617.91 Da Isoelectric Point: 5.2325
>T113014 WP_121607889.1 NZ_CP033055:3710691-3711266 [Serratia sp. 3ACOL1]
MTHSPYPALLDACVLYPARLRDLLMHLGLRGLYQPKWTAQIHDEWKRNLLVNRRDLQAEQLDRVHALMDKAMPDANVIGH
EQLVDSIRLPDQDDRHVLAAAIIANAEVIVTYNLKDFPVDYLSTFGIEAIHPDDFVSDLIDLNHALALEAVTNLRQALKN
PPMTADSFLASLAQIEMAKTVKALEDYKFIL
MTHSPYPALLDACVLYPARLRDLLMHLGLRGLYQPKWTAQIHDEWKRNLLVNRRDLQAEQLDRVHALMDKAMPDANVIGH
EQLVDSIRLPDQDDRHVLAAAIIANAEVIVTYNLKDFPVDYLSTFGIEAIHPDDFVSDLIDLNHALALEAVTNLRQALKN
PPMTADSFLASLAQIEMAKTVKALEDYKFIL
Download Length: 576 bp
>T113014 NZ_CP033055:3710691-3711266 [Serratia sp. 3ACOL1]
ATGACGCATTCGCCTTACCCAGCATTGCTTGACGCTTGTGTGCTTTACCCAGCAAGACTGCGAGACCTGTTGATGCATTT
AGGCCTAAGAGGTCTTTATCAGCCCAAATGGACAGCGCAAATCCACGACGAGTGGAAGCGTAATCTACTGGTTAATCGGC
GAGATTTGCAGGCCGAGCAGTTGGATCGCGTTCATGCTCTAATGGATAAGGCAATGCCGGATGCGAATGTGATAGGCCAC
GAACAATTGGTAGACAGCATTAGGTTACCTGACCAAGACGATCGCCATGTTCTGGCAGCTGCAATAATTGCAAACGCTGA
GGTCATCGTCACTTATAACCTTAAAGACTTTCCGGTAGATTATTTATCGACTTTTGGTATCGAAGCCATACATCCTGACG
ACTTCGTGTCAGACCTTATTGATCTTAACCATGCGTTAGCACTCGAGGCGGTGACCAATCTAAGGCAAGCACTGAAGAAT
CCCCCCATGACAGCGGATAGTTTTCTAGCTTCACTCGCTCAAATTGAGATGGCAAAAACGGTTAAGGCATTGGAAGACTA
CAAGTTCATACTATAA
ATGACGCATTCGCCTTACCCAGCATTGCTTGACGCTTGTGTGCTTTACCCAGCAAGACTGCGAGACCTGTTGATGCATTT
AGGCCTAAGAGGTCTTTATCAGCCCAAATGGACAGCGCAAATCCACGACGAGTGGAAGCGTAATCTACTGGTTAATCGGC
GAGATTTGCAGGCCGAGCAGTTGGATCGCGTTCATGCTCTAATGGATAAGGCAATGCCGGATGCGAATGTGATAGGCCAC
GAACAATTGGTAGACAGCATTAGGTTACCTGACCAAGACGATCGCCATGTTCTGGCAGCTGCAATAATTGCAAACGCTGA
GGTCATCGTCACTTATAACCTTAAAGACTTTCCGGTAGATTATTTATCGACTTTTGGTATCGAAGCCATACATCCTGACG
ACTTCGTGTCAGACCTTATTGATCTTAACCATGCGTTAGCACTCGAGGCGGTGACCAATCTAAGGCAAGCACTGAAGAAT
CCCCCCATGACAGCGGATAGTTTTCTAGCTTCACTCGCTCAAATTGAGATGGCAAAAACGGTTAAGGCATTGGAAGACTA
CAAGTTCATACTATAA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17282.76 Da Isoelectric Point: 5.9324
>AT113014 WP_024483048.1 NZ_CP033055:3710230-3710691 [Serratia sp. 3ACOL1]
MTSATFSKINLPGVQEKEIAQKGYRDLSAMLATKLDIRHFSIRDDEQNEHSIEVPPSAVKMLVEILGELANGNAVQVVPV
HAELTTQEAANLLNVSRPHVVKMLEEGKIEFHKTGRHRRIRFADLMAYKEQRDIEAAAAMDELTRLSQDMDIY
MTSATFSKINLPGVQEKEIAQKGYRDLSAMLATKLDIRHFSIRDDEQNEHSIEVPPSAVKMLVEILGELANGNAVQVVPV
HAELTTQEAANLLNVSRPHVVKMLEEGKIEFHKTGRHRRIRFADLMAYKEQRDIEAAAAMDELTRLSQDMDIY
Download Length: 462 bp
>AT113014 NZ_CP033055:3710230-3710691 [Serratia sp. 3ACOL1]
ATGACCAGTGCAACTTTTTCCAAAATCAACTTGCCTGGTGTGCAAGAAAAAGAGATTGCCCAAAAAGGTTATCGAGATTT
ATCGGCGATGTTGGCAACAAAACTAGATATTCGCCACTTCTCGATCAGAGACGATGAGCAAAATGAACACTCTATTGAGG
TTCCACCTTCTGCGGTGAAAATGCTCGTTGAGATACTAGGAGAACTAGCAAACGGGAACGCTGTTCAGGTTGTGCCCGTT
CATGCGGAATTGACTACCCAAGAAGCCGCCAATTTACTTAATGTATCCAGGCCGCATGTTGTGAAAATGCTAGAAGAAGG
CAAAATCGAATTCCATAAAACAGGGCGTCATCGCCGCATACGCTTTGCAGACCTTATGGCCTACAAAGAGCAGCGAGACA
TCGAAGCTGCTGCAGCAATGGATGAACTGACTCGTCTTTCACAGGATATGGATATCTATTAA
ATGACCAGTGCAACTTTTTCCAAAATCAACTTGCCTGGTGTGCAAGAAAAAGAGATTGCCCAAAAAGGTTATCGAGATTT
ATCGGCGATGTTGGCAACAAAACTAGATATTCGCCACTTCTCGATCAGAGACGATGAGCAAAATGAACACTCTATTGAGG
TTCCACCTTCTGCGGTGAAAATGCTCGTTGAGATACTAGGAGAACTAGCAAACGGGAACGCTGTTCAGGTTGTGCCCGTT
CATGCGGAATTGACTACCCAAGAAGCCGCCAATTTACTTAATGTATCCAGGCCGCATGTTGTGAAAATGCTAGAAGAAGG
CAAAATCGAATTCCATAAAACAGGGCGTCATCGCCGCATACGCTTTGCAGACCTTATGGCCTACAAAGAGCAGCGAGACA
TCGAAGCTGCTGCAGCAATGGATGAACTGACTCGTCTTTCACAGGATATGGATATCTATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|