Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3669274..3670859 Replicon chromosome
Accession NZ_CP033055
Organism Serratia sp. 3ACOL1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag D9980_RS16480 Protein ID WP_121607873.1
Coordinates 3669274..3670587 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag D9980_RS16485 Protein ID WP_024529137.1
Coordinates 3670587..3670859 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9980_RS16460 3665251..3666414 + 1164 WP_121607871.1 alcohol dehydrogenase -
D9980_RS16465 3666571..3667616 + 1046 Protein_3219 NAD(P)-dependent alcohol dehydrogenase -
D9980_RS16470 3667704..3668519 + 816 WP_021179533.1 2,5-didehydrogluconate reductase DkgA -
D9980_RS16475 3668659..3669264 + 606 WP_121607872.1 transglycosylase SLT domain-containing protein -
D9980_RS16480 3669274..3670587 - 1314 WP_121607873.1 type II toxin-antitoxin system HipA family toxin Toxin
D9980_RS16485 3670587..3670859 - 273 WP_024529137.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
D9980_RS16490 3671085..3673250 - 2166 WP_121607874.1 YgiQ family radical SAM protein -
D9980_RS16495 3673338..3674072 - 735 WP_121607875.1 GntR family transcriptional regulator -
D9980_RS16500 3674288..3675304 + 1017 WP_121607876.1 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49074.49 Da        Isoelectric Point: 6.9721

>T113013 WP_121607873.1 NZ_CP033055:c3670587-3669274 [Serratia sp. 3ACOL1]
MATLITWMNNELVGELTKQTTGAHTFRYDDSWMRNPRARPLSLSLPLEVGNITSDAVINYFDNLLPDNPKVRERIVKRYH
AKSTQPFDLLAEIGRDSVGAVTLLPPGKTVTELTLTWQPLDKIRLETLLTAYQSDIPLGMINEEDDFRISVAGAQEKTAL
LKINEDWCLPSGMTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGFAVPDTEIIRTETIRALAVERFDRRW
VKNRTELLRLPQEDLCQVFGLPSSVKYESDGGPGIAKIMDFLLGSSTALKDRYDFMKFQVFQWLLGATDGHAKNFSIFIQ
AGGSFRLTPFYDIISAFPVLGGQGLHMSDLKLAMSLKASKGRKNEIGKIYPRHFVATAKEVNFPAEQMMEILHYFAENVP
RAIDAVTKTLPGDFSTHVYRSIVSNLQKFHGRLSGIA

Download         Length: 1314 bp

>T113013 NZ_CP033055:c3670587-3669274 [Serratia sp. 3ACOL1]
ATGGCAACGCTTATTACGTGGATGAACAACGAACTAGTCGGTGAGTTGACGAAGCAGACAACCGGTGCGCATACGTTCAG
ATATGATGATAGTTGGATGCGCAATCCGCGCGCTAGGCCTCTTTCTCTATCTCTGCCTTTAGAGGTAGGCAACATCACAT
CTGATGCGGTGATTAACTACTTTGATAACCTGTTGCCGGACAACCCAAAGGTTCGGGAGCGAATTGTTAAAAGGTATCAC
GCCAAATCGACACAACCCTTTGATCTTCTTGCCGAGATAGGGAGAGATAGTGTGGGAGCTGTGACGTTACTTCCGCCAGG
GAAAACTGTCACCGAACTGACATTAACATGGCAGCCACTGGATAAAATCCGACTGGAAACGTTACTCACCGCATACCAAT
CAGATATTCCGCTTGGCATGATTAATGAAGAAGACGATTTCAGAATATCGGTTGCAGGTGCCCAGGAAAAGACGGCGCTG
CTGAAGATTAATGAGGATTGGTGTCTCCCGAGTGGAATGACGCCAACTACCCACATCATTAAGCTGCCGATAGGCGAAAT
AAAACAGCCTAATGCCACGCTGGATCTGCGTGAGAGTGTTGATAATGAATATTTATGTCTGGCATTAGCACGTGAACTTG
GATTTGCTGTGCCTGATACCGAGATCATCAGGACTGAGACCATCAGGGCTCTGGCAGTTGAACGGTTTGATCGTCGCTGG
GTGAAGAACAGAACCGAGTTGCTTCGCTTGCCGCAAGAAGATCTCTGCCAAGTTTTCGGTCTGCCCTCATCAGTGAAGTA
TGAATCAGACGGGGGGCCAGGAATTGCCAAGATCATGGATTTTTTGCTTGGTTCCAGCACCGCGTTAAAAGACCGATATG
ACTTTATGAAATTTCAGGTTTTTCAATGGCTGCTTGGTGCAACGGATGGGCATGCGAAAAATTTCTCCATTTTTATTCAG
GCAGGCGGTAGCTTTAGATTAACTCCCTTCTACGACATTATTTCTGCCTTTCCCGTGCTCGGTGGGCAAGGTTTACATAT
GAGCGATCTTAAGTTGGCAATGAGCCTGAAAGCCAGCAAGGGAAGGAAAAACGAGATTGGCAAGATCTATCCCCGTCACT
TTGTGGCGACAGCAAAGGAGGTGAATTTCCCCGCAGAGCAAATGATGGAGATCCTGCATTATTTCGCGGAGAACGTTCCG
AGAGCCATCGATGCGGTAACAAAAACTTTACCTGGCGATTTTTCAACCCATGTCTACCGCTCCATCGTGTCAAATTTGCA
GAAATTCCACGGTAGGTTATCAGGGATAGCCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10343.87 Da        Isoelectric Point: 6.9472

>AT113013 WP_024529137.1 NZ_CP033055:c3670859-3670587 [Serratia sp. 3ACOL1]
VMSPPKIYSPAQLANYLKLVRQRNHWTQSDLAGRIGIKQATISNFENNPEKTTLTTLFKILQSLEMSMVVCEKNDMTAVC
DKENQQELDW

Download         Length: 273 bp

>AT113013 NZ_CP033055:c3670859-3670587 [Serratia sp. 3ACOL1]
GTGATGAGTCCACCAAAAATTTATAGCCCGGCCCAACTGGCAAACTATCTAAAACTAGTGCGGCAGAGAAACCATTGGAC
GCAAAGCGATCTTGCCGGTCGGATCGGTATTAAGCAGGCAACCATTTCCAACTTCGAAAACAACCCCGAAAAAACAACGC
TAACTACGCTGTTTAAAATATTGCAATCACTTGAAATGTCTATGGTTGTATGCGAAAAAAATGATATGACAGCCGTCTGT
GATAAGGAAAATCAACAGGAGCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References